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IRCT20140107016117N3 IRCT 2020-01-05 Tabriz University of Medical Sciences Effect of Premedication with oral clonidine on hemodynamic status of patients Effect of Premedication with oral clonidine on hemodynamic status of patients under thyroidectomy 2019-12-22 anticipated 100 Complete https://irct.ir/trial/44302 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study we use balanced randomization that at first four blocks with 9 combination will be formed and blocks will be numbered from 1to9. Compared to the simple randomization method, in this method the size of equilibrium of intervention and placebo groups will be established both during and at the end of study(randomization method is pre and post accidental blocks and will be done by randlist software), Blinding description: The anesthesiologist who has responsible for the patients management of anesthesia will administer the medicine(s) via coded syringes had been prepared previously and will not aware of the injected drug(clonidine or pelacebo ), and anesthesia nurse who is responsible for collection of patients information and study variables and is unaware of the administered drug will record the check- list during surgery and in the recovery.Also the patient is unaware of the injected medicine. 3 The effect of oral clonidine on hemodynamic changes after thyroid surgery. Intervention 1: Intervention group:The patients of this group received 0.2 mg clonidine orally with water . Intervention 2: Control group: this group receive placebo similar to intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Bahman Naghipour
Departement of Anesthesiology, Faculty of Medicine, Golgasht Street
Tabriz Iran (Islamic Republic of) 5166614766 +98 41 3334 1994 naghipourb@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Bahman Naghipour
Departement of Anesthesiology, Faculty of Medicine, Golgasht Street
Tabriz Iran (Islamic Republic of) 5166614766 +98 41 3334 1994 naghipourb@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) All ASA II patients aged 18-60 years who are candidate for total elective thyroidectomy surgery. 18 years 60 years Both Patients with systemic diseases(cardiovascular, pulmonary, liver and kidney,...) Blood loss over 10% Prediction of patients with difficult airways Drug addiction Use medicines Interfering with clonidine drugs such as Ibuprofen, Metalol, losartan, beta-blockers, diazepam and vitamin B12. T88.59 Other complications of anesthesia Treatment - Drugs Treatment - Drugs Intervention group:The patients of this group received 0.2 mg clonidine orally with water . Control group: this group receive placebo similar to intervention group. Systolic and diastolic blood pressure. Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes. Method of measurement: Mercury barometer. Mean arterial pressure(MAP). Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes. Method of measurement: Mercury barometer. Heart rate. Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes. Method of measurement: Counting in each minutes. Partial pressure of end tidal of carbondioxide. Timepoint: From the beginning of anesthesia and then every 30 minutes. Method of measurement: Using the Copnograph. Saturation of peripheral oxygen. Timepoint: From the beginning of anesthesia and then every 30 minutes. Method of measurement: Via the Pulse Oximeter. Tabriz University of Medical Sciences Approved 2019-12-09 Ethics committee of Tabriz University of Medical Sciences Faculity of Medicine, Golgasht Street Tabriz East Azarbaijan Iran (Islamic Republic of)