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IRCT20191217045766N1 IRCT 2021-11-24 Kurdistan University of Medical sciences Evaluation of the Effect of Donepezil on the Methadone Consumption Evaluation of the Effect of Donepezil on the Methadone Consumption in Methadone Maintenance 2021-12-16 anticipated 100 Complete https://irct.ir/trial/44274 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to intervention and control groups using block randomization. For this purpose, we will prepare four sheets of paper, writing on two sheets the name of the intervention and on the other two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are drawn. The four paper sheets will be then placed back into the container, and this action repeated until the sample size is reached, Blinding description: Participants, physicians, and analysts are unaware of who is receiving what medication. Therefore, the study is performed in a triple blinded. 2-3 amount of Methadon use. Dopezil Sobhan Pharmaceutical Company Start with 5 mg oral tablets once a day for 4 weeks and then 10 mg tablets once a day until the end of week 14. No - There is not a plan to make this available Justification or reason for not sharing IPD is there is no more information
public Modabber Arasteh
Qods hospital., Shohadaie Niruie Entezani Blvd., Pasdaran Blvd
Sanandaj Iran (Islamic Republic of) 6617713141 +98 87 3366 0026 arastehmd@yahoo.com Kurdistan University of Medical Sciences scientific Modabber Arasteh
Qods hospital., Shohadaie Niruie Entezami Blvd., Pasdaran Blvd
Sanandaj Iran (Islamic Republic of) 6617713141 +98 87 3366 0026 arastehmd@yahoo.com Kurdistan University of Medical Sciences Iran (Islamic Republic of) All opioid dependent patients on Methadone agonist therapy in the age range of 18 to 55 years At least fifth grade elementary education 18 years 55 years Both Intellectual Disability Use if Anti Depressant, Carbamazepin, Dexamethasone, Phenobarbital, Phenytoin, Rifampin, Clonidine, Sox, Betanecol Use of Donepezil during 3 months ago CAD Pregnancy and Lactation major psychiatric disorder Use of Psychotherapy Sever sensitivity to Donepezil Treatment - Drugs Dopezil Sobhan Pharmaceutical Company Start with 5 mg oral tablets once a day for 4 weeks and then 10 mg tablets once a day until the end of week 14 Amount of Methadon use. Timepoint: at the beginning of the study,weeks of 4, 10 and 14. Method of measurement: patients report. Craving for Methadon. Timepoint: at the beginning of the study,weeks of 4, 10 and 14. Method of measurement: HALIKAS Questionnaire. Kurdistan University of Medical sciences Approved 2020-03-14 Ethic commitment of Kurdistan University of Medical Sciences Kurdistan University of Medical Sciences, Pasdaran Blv Sanandaj Kurdistan Iran (Islamic Republic of)