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IRCT20141009019470N95 IRCT 2020-01-14 Shiraz University of Medical Sciences The comparison of two drug regimen: Isofluran-Remifentanil and Propofol -Remifentanil in blood pressure control and surgeon satisfaction in rhinoplasty surgery The comparison of two drug regimen: Isofluran-Remifentanil and Propofol -Remifentanil in blood pressure control and surgeon satisfaction in rhinoplasty surgery 2020-02-04 anticipated 100 Complete https://irct.ir/trial/44245 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients were randomly divided into two groups, I-R and P-R, using the randomization table from Randomization.com, Blinding description: Anesthesia nurse who is present in the operating room will not provide any information to the recovery staff after the surgery and deliver the patient to the recovery room, while, the patient, nurse, recovery officer, and data analyst will be briefed on the study. Have been blinded. 2-3 Rhinoplasty surgery. Intervention 1: Intervention group:In the propofol and remifentanil group, patients receive propofol 50-100 µg / kg and remifentanil 0.40.1 µg / kg for maintenance of anesthesia. Intervention 2: Intervention group:In the isoflurane and remifentanil group, anesthesia will be maintained with a maintenance dose of isoflurane (MAC1.25%) plus remifentanil 0.40.1 mcg / kg. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Its against our policies.
public Razieh Abbasi
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3647 4270 Razieh.8496@gmail.com Shiraz University of Medical Sciences scientific Laleh Dehghanpishe
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3647 4270 Lalehdehghan@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients Candidate for Rhinoplasty Surgery Age 18-50 years (ASA) I, II 18 years 50 years Both Allergy to propofol and isoflurane or remifentanil Hypertension Cardiac Disease Anemia Liver Disease Kidney Disease CNS Disease Previous Septo-rhinoplasty COPD Disease Sever Asthma Z41.1 Encounter for cosmetic surgery Prevention Prevention Intervention group:In the propofol and remifentanil group, patients receive propofol 50-100 µg / kg and remifentanil 0.40.1 µg / kg for maintenance of anesthesia. Intervention group:In the isoflurane and remifentanil group, anesthesia will be maintained with a maintenance dose of isoflurane (MAC1.25%) plus remifentanil 0.40.1 mcg / kg. Blood Pressure. Timepoint: Every 5 minutes in the operating room until the end of surgery and every 15 minutes in the recovery room until discharge. Method of measurement: Monitoring. Surgeon satisfaction. Timepoint: End of surgery. Method of measurement: Likert scale. Heart Rate. Timepoint: Continuously during surgery until the end of recovery. Method of measurement: Monitoring. Arterial Oxygen Saturation Percentage. Timepoint: Continuously during surgery until the end of recovery. Method of measurement: Pulse-oximeter. Shiraz University of Medical Sciences Approved 2019-12-14 Ethics Committee of Shiraz University of Medical Sciences Vice Chancellor of research, Shiraz University of Medical Sciences, 7th floor, central building of Shiraz University of Medical Sciences, Zand street Shiraz Fars Iran (Islamic Republic of)