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IRCT20191211045700N1 IRCT 2020-08-05 Rasht University of Medical Sciences The effect of positive end expiratory pressure (PEEP) changes on central venous pressure The effect of positive end expiratory pressure (PEEP) changes on central venous pressure in hospitalized patients in Intensive care unit 2019-12-22 anticipated 70 Complete https://irct.ir/trial/44218 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Blinding description: Supervisor has no information about peep and just measures CVP. Patients are not aware of the events due to intubation and receiving anesthesia drugs. N/A Patients who are over 18 years old with CV line, and are under mechanical respiration with stable vital signs and are hospitalized in ICU ward of Poursina Hospital in Rasht. Patients with various diseases such as trauma, CVA, sepsis and ... are hospitalized in this ward.. Intervention group: Intubated patients connected to a ventilator with one type of sedation drug and one type of ventilator settings will enter the study. Patient demographics will be recorded in pre-designed checklists. To reduce the incidence of error, patients with a right subclavian vein catheter will be included in the study.Patients' CVP will be measured after ten minutes in peep 3, 5, 7. Then the CVP number and its changes in the three measured pipes (3, 5 and 7) will be recorded in the checklists.Also, all measurements will be performed by one person (emergency medicine resident who is not in the study and does not know Peep status (for blindness)) and at the level of par with the sternum angle and with a special CVP ruler. Then the changes of CVP in different pipes (peep from 3 to 5, 5 to 7 and also 3 to 7) will be examined and will be analyzed by statistical tests.. Yes - There is a plan to make this available What will be shared: The data about the main outcome will be given to the applicants after deleting the patients' personal information in SPSS file format. When: Three months after finishing of study. To whom: The researchers in medical centers Conditions: To compare with other studies and also for estimating sample size. Where to obtain: To receive more information, be in contact with Dr. Seyed Mehdi Zia Ziaberi via drziabari@gums.ac.ir mail address. How to obtain: A request letter and information related to researcher including his/her ID card would send them to the mentioned e-mail address. The information will be sent within 15 days after receiving the request. Comments:
public Seyyed Mahdi Zia Ziabari
Poursina hospital, Poursina intersection
Rasht Iran (Islamic Republic of) 4193713194 +98 13 3333 9842 drziabari@gums.ac.ir Rasht University of Medical Sciences scientific Seyyed Mahdi Zia Ziabari
Poursina hospital, Poursina Intersection
Rasht Iran (Islamic Republic of) 4193713194 +98 13 3333 9842 drziabari@gums.ac.ir Rasht University of Medical Sciences Iran (Islamic Republic of) Being at the age of 18 years and over Intubated patients connected to the ventilator Patients with right subclavian CV line Stable vital sign 18 years no limit Both Patients who need more than 200 cc serum per hour Patients with auto peep Patients who need more than 10 cmH2O peep Sudden changes in vital sign with peep change lung injury Chronic obstructive pulmonary diseases (COPD) Asthma Valve disorders Acute respiratory distress syndrome (ARDS) BMI>30 Dissatisfaction of relatives Z99.11 Dependence on respirator [ventilator] status Treatment - Other Intervention group: Intubated patients connected to a ventilator with one type of sedation drug and one type of ventilator settings will enter the study. Patient demographics will be recorded in pre-designed checklists. To reduce the incidence of error, patients with a right subclavian vein catheter will be included in the study.Patients' CVP will be measured after ten minutes in peep 3, 5, 7. Then the CVP number and its changes in the three measured pipes (3, 5 and 7) will be recorded in the checklists.Also, all measurements will be performed by one person (emergency medicine resident who is not in the study and does not know Peep status (for blindness)) and at the level of par with the sternum angle and with a special CVP ruler. Then the changes of CVP in different pipes (peep from 3 to 5, 5 to 7 and also 3 to 7) will be examined and will be analyzed by statistical tests. Central venous pressure (CVP). Timepoint: After 10 minutes being on peep 3, 5 and 7. Method of measurement: CV line. Rasht University of Medical Sciences Approved 2019-10-20 Ethics Committee of Guilan University of Medical Sciences Namjoo street Rasht Guilan Iran (Islamic Republic of)