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IRCT201308204191N2 IRCT 2013-09-08 Atieh NEuroscience Center The Study of effectiveness of repetitive transcranial magnetic stimulation in Patients with Bipolar Depression The Comparison of effectiveness of Bilateral repetitive transcranial magnetic stimulation Versus Unilateral repetitive transcranial magnetic stimulation in Patients with Bipolar Depression: a study randomized and Single blind 2013-08-23 anticipated 30 Complete https://irct.ir/trial/4419 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Bipolar Depression. Intervention 1: 1Hz unilateral repetitive transcranial magnetic stimulation is applied during 40 minutes in 20 sessions. Intervention 2: 10 Hz and 1Hz bilateral repetitive transcranial magnetic stimulation are applied during 40 minutes in 20 sessions.
public Sanaz Khomami
No 23, Above of vanak Sq, Vali-nezhad St
Tehran Iran (Islamic Republic of) +98 21 8401 2121 skhomami@ut.ac.ir Atieh neuroscience center scientific Reza Kazemi
No 23, Above of vanak Sq, Vali-nezhad St
Tehran Iran (Islamic Republic of) +98 21 8401 2121 rezakazemi@ut.ac.ir Atieh neuroscience center Iran (Islamic Republic of) Inclusion Criteria: Outpatients male and female with the range of 18-65 years of age; The diagnosis of Bipolar disorder according to DSM-IV-TR; Completion of Consent Form; Being under Supervision of a psychiatrist; BDI-II score >14; Being able to adhere to treatment Schedule; Having stable symptoms as defined by not requiring a change in medication for at least 4 weeks Exclusion Criteria: The history of rTMS treatment for any reason; Intracranial Implant and other ferromagnetic materials close to the head; Cardiac Pacemaker, drug Pumps, acute heart attack; having personality disorders in Axis II; The risk of Seizure with any reasons, high Intracranial pressure, The history of epilepsy or Seizure in the first relatives, any metal in Head, brain trauma, history of loss of consciousness for more than 5 minutes; Pregnancy, breastfeeding; High risk of Suicide. 18 years 65 years Both F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms Treatment - Devices Treatment - Devices 1Hz unilateral repetitive transcranial magnetic stimulation is applied during 40 minutes in 20 sessions. 10 Hz and 1Hz bilateral repetitive transcranial magnetic stimulation are applied during 40 minutes in 20 sessions Bipolar Depression. Timepoint: Befor intervention, ten Session, after intervention. Method of measurement: Beck Depression Inventory. Anxiety. Timepoint: Befor intervention, Session ten,After Intervention. Method of measurement: Beck anxiety Inventory. Qulaity of Life. Timepoint: Befor intervention, Session ten,After Intervention. Method of measurement: WHOQol-Brief Form. Brain waves. Timepoint: Befor intervention, Session ten,After Intervention. Method of measurement: Quantitiative EEG ( QEEG). NCT01932749 www.clinicaltrials.gov Atieh NEuroscience Center Approved 2013-05-25 University Of Tehran Faculty of Psychology & Education University of Tehran Jalal Al-e-Ahmad Ave. Tehran Iran (Islamic Republic of)