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IRCT20191211045702N1 IRCT 2019-12-23 Hamedan University of Medical Sciences Assessment of the effect of aspirin on periapical inflammation Assessment of the effect of aspirin on levels of lipoxin A4، interleukin-1β and prostaglandin E2 in periapical exudates: a double blinded randomized clinical trial 2020-01-21 anticipated 30 Complete https://irct.ir/trial/44185 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization with size 4, Blinding description: The random process will be performed by someone outside the core research team, and the patient and physician will not know which group the patient is in. 3 Apical periodontitis. Intervention 1: Intervention group: 7 pills of aspirin 80 mg for 7 days. Intervention 2: Control group: 7 tablets containing sodium saccharin for 7 days. Yes - There is a plan to make this available What will be shared: Results of the main outcome include the concentation of inflammatory mediators in the periapical exudate When: after publication of the final article To whom: En researchers who works in university Conditions: the data will provide for using in review studies or future clinical trials if cited as regular Where to obtain: r.salehi70510@gmail.com, 09171435936,Razieh Salehi How to obtain: requesting via email that takes maximum one month after receiving the request Comments:
public Razieh Salehi
Shahid Fahmideh Ave
Hamadan Iran (Islamic Republic of) 6517838677 +98 81 3838 1086 r.salehi70510@gmail.com Hamedan University of Medical Sciences scientific Razieh Salehi
Endodontics Department, Dental University, Shahid Fahmideh Ave, Hamedan Town
Hamedan Iran (Islamic Republic of) 6517838677 +98 81 3838 1086 razieh.salehi@edu.umsha.ac.ir Hamedan University of Medical Sciences Iran (Islamic Republic of) Patients with good general health Patients aged 18-45 years All single root, distal root of mandibular molars and palatal root of maxillary molars with periapical lesion of >5 mm in diameter Tooth with no history of trauma and previous root canal treatment 18 years 45 years Both Unable to isolate tooth Presence of periodontal disease Presence of systemic disease History or presence of other infections Specific physiological conditions Oral ulcer Smokers and alcoholics Gastrointestinal problems Treatment with any drug over the past week Sensitivity to salicylates or other non-steroidal anti-inflammatory drugs K04.5 Chronic apical periodontitis Treatment - Drugs Placebo Intervention group: 7 pills of aspirin 80 mg for 7 days Control group: 7 tablets containing sodium saccharin for 7 days Concentration of inflammatory mediator. Timepoint: At baseline and 7 days later. Method of measurement: Enzyme-linked immunosorbent kit. Hamedan University of Medical Sciences Approved 2019-11-23 Ethics committee of Hamadan University of Medical Sciences Shahid Fahmideh Ave, dentistry school Hamadan Hamadan Iran (Islamic Republic of)