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IRCT20141209020258N126 IRCT 2019-12-17 Arak University of Medical Sciences Ampicillin-sulbactam basecompared Colistin Basefor the treatment of ‎acintobacter resistant to carbapenems in ventilator associated pneumonia ‎ Ampicillin-sulbactam basecompared Colistin Basefor the treatment of ‎acintobacter resistant to carbapenems in ventilator associated pneumonia ‎ 2018-06-22 anticipated 66 Complete https://irct.ir/trial/43955 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with randomization with envelopes in two groups A and B.‏ In this method, we selected a number of cards or letters as an intervention group and the same ‎number of cards for the control group, then the cards were merged. One card was taken out and its ‎allocation was registered and the card was returned to the other cards after leaving. Then the cards ‎are merged again and we remove another card. This process continues to reach a random sequence ‎according to sample size, Blinding description: This study is double blind. Researcher who complete questionnaire and analyzer are blind (double blind). Outcome assessor and analyzer don't aware from grouping.The person evaluating the outcome is unaware of the grouping. Groups A and B are available to analyzer and outcome assessor.In order to blind in two groups, the syringe covered with white paper on which they are written A and B. 3 ventilator associated pneumonia ‎. Intervention 1: Intervention group: Cholestine plus Carbapenem is prescribed in doses based on renal clearance and milligram in kilogram and converted to millions of units intravenously. We inject 500 gram Imipenem every 6 hours and meropenem 1 gram every 8 hours. Intervention 2: Intervention group: We inject Ampicillin / sulbactam and Carbapenem. We inject 9 grams of ampicillin / sulbactam three times daily, which can be adjusted based on renal clearance. Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: researcher in university Conditions: If there are additional questions Where to obtain: Dr Masoumeh Sofian How to obtain: They have to write letters to the professors and the university Comments:
public Dr Masoumeh Sofian
Arak, Valiasr Hospital
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 sofian@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Masoumeh Sofian
Arak, Valiasr Hospital
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 sofian@arakmu.ac.ir Arak University of Medical Sciences Iran (Islamic Republic of) Ages over 16 years Ventilator-induced pneumonia with carbapenem-producing acinetobacter 16 years no limit Both Failure to complete the course of treatment and discontinuation of treatment (due to drug complications and death, etc.) Dissatisfaction J95.851 Ventilator associated pneumonia Treatment - Drugs Treatment - Drugs Intervention group: Cholestine plus Carbapenem is prescribed in doses based on renal clearance and milligram in kilogram and converted to millions of units intravenously. We inject 500 gram Imipenem every 6 hours and meropenem 1 gram every 8 hours. Intervention group: We inject Ampicillin / sulbactam and Carbapenem. We inject 9 grams of ampicillin / sulbactam three times daily, which can be adjusted based on renal clearance. White blood cell count. Timepoint: First study, third day, seventh day and 14th day. Method of measurement: Blood test. Erythrocyte sedimentation rate. Timepoint: First study, third day, seventh day and 14th day. Method of measurement: Blood test. Culture of lung secretions. Timepoint: First study, third day, seventh day and 14th day. Method of measurement: Culture of lung secretions test. Arak University of Medical Sciences Approved 2018-06-17 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)