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IRCT20170615034549N2 IRCT 2020-06-17 Kashan University of Medical Sciences Evaluation the effect of probiotic on drug-resistant epilepsy Evaluation the effect of probiotic supplementation on clinical symptoms and biochemical indices in children with drug-resistant epilepsy 2019-10-27 anticipated 40 Complete https://irct.ir/trial/43877 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Drug resistant epilepsy. Intervention group: children with Drug resistant epilepsy that are received oral probiotic supplementation as daily with 2 month. The probiotic supplement is Prokid from Gostaresh Milad Farmed Co., which contains beneficial bacteria ,Bifidobacterium lactis, Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus rhamnos with 6×109 CFU concentration.. Yes - There is a plan to make this available What will be shared: Publishing results as a paper When: permanently as a paper To whom: All people Conditions: For research and therapeutic aims (if possible) Where to obtain: Dr. Salami How to obtain: Simply accessibility to the published paper Comments:
public Dr Ahmad Talebian
Ghotb Ravandi Blvd
Kashan Iran (Islamic Republic of) 8715973447 +98 31 5554 0027 talebian_a@kaums.ac.ir Kashan University of Medical Sciences scientific Mahmoud Salami
Ghotb ravandi Blvd
kashan Iran (Islamic Republic of) 8715988141 +98 31 5562 1157 salami-m@kaums.ac.ir Kashan University of Medical Sciences Iran (Islamic Republic of) Patients with a diagnosis of refractory epilepsy. Patients are between 3 and 15 years old. children who have a medical record with a medical doctor and have been referred to the pediatric neurosurgery clinic of Shahid Beheshti Hospital for treatment. They have had at least one seizure in the past three months. 3 years 15 years Both Children that the cause of their seizures are secondary such as electrolyte imbalances Children with underlying, genetic or progressive brain diseases. Children who have had probiotic use for one month before the study. Children who take antibiotics with any reason for one month before the study. Children who take any immunosuppressant medication with any reason for one month before the study. Children who take any vitamin or mineral supplement except vitamin D G40 Epilepsy and recurrent seizure Treatment - Drugs Intervention group: children with Drug resistant epilepsy that are received oral probiotic supplementation as daily with 2 month. The probiotic supplement is Prokid from Gostaresh Milad Farmed Co., which contains beneficial bacteria ,Bifidobacterium lactis, Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus rhamnos with 6×109 CFU concentration. Seizure frequency. Timepoint: before and after probiotic treatment. Method of measurement: asking frequency of seizure frequency. Blood indices(Sodium- calcium - potassium - magnesium - hepatic enzymes including alkaline phosphatase, AST and ALT- bilirubin - creatinin). Timepoint: before and after. Method of measurement: Measurement of venous blood sample. Kashan University of Medical Sciences Approved 2019-10-27 Kashan University of Medical Sciences Physiology Research Center, Institute of Basic Sciences, Kashan University of Medical Sciences, Kashan, I. R. Iran Kashan Isfehan Iran (Islamic Republic of)