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IRCT20110731007160N8 IRCT 2020-08-16 Shiraz University of Medical Sciences Evaluation of the Effectiveness of Microneedling versus Microdermabrasion for Preparation of Lesion Site for Autologous Melanocyte and Keratinocyte Transplantation in Patients with Vitiligo Stable Lesion Evaluation of the Effectiveness of Microneedling versus Microdermabrasion for Preparation of Lesion Site for Autologous Melanocyte and Keratinocyte Transplantation for Cell Therapy in Patients with Vitiligo Stable Lesion: A pilot study 2021-01-19 anticipated 10 Complete https://irct.ir/trial/43820 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 1 Vitiligo. A piece of pigmented skin is disinfected with a chlorhexidine solution and then anesthetized with lidocaine, and then an area of ​​2 to 4 cm of skin is removed and the wound sutured. Then the melanocyte and keratinocyte cells are separated from the epidermis. Then two different vitiligo lesions of the same patient are prepared by micro-needling and dermabrasion, respectively, and the prepared cell suspension is spread over these two areas, these lesions are then covered with amniotic membranes.. Yes - There is a plan to make this available What will be shared: Demographic characteristics of the results of cell therapy in vitiligo patients When: Immediately after the publication of the article To whom: Researchers Conditions: Send researchers' requests via email and make a commitment to applicants to protect the data Where to obtain: Sending researchers' requests via e-mail to the e-mail address of the executor and in charge of the project, Dr. Nasrin Hamidizadeh. n.hamidizadeh.mdrc@gmail.com How to obtain: The applicant researcher should send his request to the email address of the executor of the project, Dr. Nasrin Hamidizadeh (n.hamidizadeh.mdrc@gmail.com). Within one week after evaluation, the data will be sent to the applicant via email, along with making a commitment. Comments:
public Dr.Nasrin Hamidizadeh
Molecular Dermatology Research Center Shahid Faghihi hospital, Zand Avenue, Shiraz-Iran
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3212 5592 n.hamidizadeh.mdrc@gmail.com Shiraz University of Medical Sciences scientific Dr.Nasrin Hamidizadeh
Molecular Dermatology Research Center Shahid Faghihi hospital, Zand Avenue, Shiraz-Iran
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3212 5592 n.hamidizadeh.mdrc@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients who have stable vitiligo Patients whose disease has not progressed and whose disease stability is confirmed by the absence of new lesions during the last year from the patient-reported medical history. 18 years 50 years Both Patients with more than 30% body surface involvement, and patients who receive other treatments for vitiligo, are not included in the study. pregnant women patients with skin cancer and other vitiligo treatments L80 Vitiligo Treatment - Other A piece of pigmented skin is disinfected with a chlorhexidine solution and then anesthetized with lidocaine, and then an area of ​​2 to 4 cm of skin is removed and the wound sutured. Then the melanocyte and keratinocyte cells are separated from the epidermis. Then two different vitiligo lesions of the same patient are prepared by micro-needling and dermabrasion, respectively, and the prepared cell suspension is spread over these two areas, these lesions are then covered with amniotic membranes. Melanin pigment production rate in skin. Timepoint: After 3 to 6 weeks of treatment. Method of measurement: Vitiligo Area Scoring Index (VASI). Shiraz University of Medical Sciences Approved 2020-04-08 Ethics committee of Shiraz University of Medical Sciences Molecular Dermatology Research Center Shahid Faghihi hospital, Zand Avenue, Shiraz-Iran shiraz Fars Iran (Islamic Republic of)