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IRCT20191106045356N5 IRCT 2021-05-01 Yazd University of Medical Sciences Clinical evaluation of the effect of Glycyrrhiza glabra root hydroalcoholic extract on the second degree burn wound healing Clinical evaluation of the effect of Glycyrrhiza glabra root hydroalcoholic extract on the second degree burn wound healing. 2021-03-02 anticipated 48 Complete https://irct.ir/trial/43635 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients with 2 degree burn who meet the inclusion criteria are placed in one of two groups A or B using random numbers obtained from the RAND function of Excel software. Licorice hydrogels or base hydrogels are each placed in a uniform container labeled A or B. So that only the first executor of the project is aware of the content of these containers and none of the doctors and patients know the content of each container, Blinding description: Different groups of drugs are placed in uniform and coded containers, and the prescribing physician and the evaluator do not know the composition and content of each drug container. 3 Burn. Intervention 1: Intervention group: Patients with hydrogel containing licorice will be treated topically for 15 days and standard treatment. Patients will be instructed to use only the products mentioned in the study and the necessary warnings will be given about using other household products. Treatment of the lesion condition is evaluated for the severity of redness, burning, edema, inflammation and pain (score 0 to 4). Patients will take the prescribed medication daily. After starting treatment, patients are evaluated every 5 days for the severity of redness, burning, edema, inflammation and pain. Intervention 2: Control group: Patients with hydrogel base will be treated topically for 15 days and standard treatment. Patients will be instructed to use only the products mentioned in the study and the necessary warnings will be given about using other household products. Treatment of the lesion condition is evaluated for the severity of redness, burning, edema, inflammation and pain (score 0 to 4). Patients will take the prescribed medication daily. After starting treatment, patients are evaluated every 5 days for the severity of redness, burning, edema, inflammation and pain. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) 8916774520 +98 35 3820 3865 mzabihi100@gmail.com Yazd University of Medical Sciences scientific Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) 8916774520 +98 35 3820 3865 mzabihi100@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) Patients with grade 2 burns. Hip patients 16 to 65 years. The burn must have occurred 24 hours before the start of treatment and involved less than one and a half percent of the body surface. 16 years 65 years Both Patients with skin diseases. Allergy to silver sulfadiazine or licorice. Severe systemic diseases such as uncontrolled diabetes, epilepsy, immunodeficiency and pregnant women. Treatment - Drugs Placebo Intervention group: Patients with hydrogel containing licorice will be treated topically for 15 days and standard treatment. Patients will be instructed to use only the products mentioned in the study and the necessary warnings will be given about using other household products. Treatment of the lesion condition is evaluated for the severity of redness, burning, edema, inflammation and pain (score 0 to 4). Patients will take the prescribed medication daily. After starting treatment, patients are evaluated every 5 days for the severity of redness, burning, edema, inflammation and pain. Control group: Patients with hydrogel base will be treated topically for 15 days and standard treatment. Patients will be instructed to use only the products mentioned in the study and the necessary warnings will be given about using other household products. Treatment of the lesion condition is evaluated for the severity of redness, burning, edema, inflammation and pain (score 0 to 4). Patients will take the prescribed medication daily. After starting treatment, patients are evaluated every 5 days for the severity of redness, burning, edema, inflammation and pain. Burn wound healing score. Timepoint: before intervention and 3, 10 weeks after intervention. Method of measurement: Visual Analogue Scale. School of Pharmacy Approved 2019-09-01 Ethics committee of Shahid Sadoughi University of Medical Sciences Alem sq. Yazd Yazd Iran (Islamic Republic of)