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IRCT20191106045347N1 IRCT 2020-06-30 Shahid Beheshti University of Medical Sciences Randomized comparison of intravenous magnesium sulfate VS subligual nitroglycerin spray on Uterine hypercontractility during labor in Mahdieh-hospital Randomized comparison of intravenous magnesium sulfate VS subligual nitroglycerin spray on Uterine hypercontractility during labor in Mahdieh-hospital 2020-05-04 anticipated 50 Complete https://irct.ir/trial/43555 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were randomly assigned (Using random table of numbers) to be divided into two groups. One group of candidates received magnesium sulfate at 4 g intravenous infusion within ten minutes, and the other candidate received a subcutaneous spray of nitroglycerin spray. The even numbers will belong to the first group and the odd numbers will belong to the second group. 1-2 increased uterine activity during childbirth. Intervention 1: Intervention group 1: Receiving magnesium sulfate in the amount of 4 g intravenous infusion within ten minutes. Intervention 2: Intervention group 2: Get a sublingual spray nitroglycerin spray puff. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Maryam Azad
No. 8, Unit 6, West Golestan St., 22 Eskandar St., East Prophet, Ashrafi Isfahani Intersection
Tehran Iran (Islamic Republic of) 19839-63113 +98 21 2243 9770 Azad@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Maryam Azad
No. 8, Unit 6, West Golestan St., 22 Eskandar St., East Prophet, Ashrafi Isfahani Intersection
Tehran Iran (Islamic Republic of) 19839-63113 +98 21 2243 9770 Azad@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Healthy women without underlying disease Single pregnancy pregnancy A healthy fetus with a normal heart rate Pregnancy over 37 weeks (semester and post semester) Spontaneous labor pain or induced by misoprostol or oxytocin 18 years 50 years Female Contraindications to MgSo4 include Myasthenia Gravis, advanced muscle weakness, a history of allergy to MgSo4, severe renal impairment, and heart block. Restricted fetal growth, abnormalities and known fetal anomalies Fetal distress Chorioamnionitis placenta previa,placenta acaeta-increta-precreta Multiple pregnancies Patient dissatisfaction Polyhydramnios Previous cesarean section Oct positive test Take any medication other than multivitamins, multivitamins and iron Pregnant women with underlying diseases such as diabetes, high blood pressure, heart disease and so on Nitroglycerin contraindications Acute circulatory failure such as shock collapse system circulatory system Clear hypotension in systolic blood pressure less than 90 Severe anemia (hemoglobin less than 7) Treatment - Drugs Treatment - Drugs Intervention group 1: Receiving magnesium sulfate in the amount of 4 g intravenous infusion within ten minutes. Intervention group 2: Get a sublingual spray nitroglycerin spray puff. Uterine activity during delivery. Timepoint: During delivery. Method of measurement: In the second stage of labor, the number of contractions will be recorded in ten minutes. Number of uterine contractions. Timepoint: During excessive uterine activity during induction of labor. Method of measurement: More than 5 contraction within 10 minutes during induction of labor. Shahid Beheshti University of Medical Sciences Approved 2019-06-24 Ethics Committee of Shahid Beheshti University of Medical Sciences Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)