IRCT138903204113N2 IRCT 2012-11-28 Pediatric health research center of Tabriz university of medical sceinces Benefits and complication of peripherally inserted central catheter (PICC) versus peripherally Intravenous Vein lines Early Outcome of peripheraly inserted central catheter(PICC)versus peripheraly conulation(PC) in very low birth weight (VLBW)infants. infants 2012-05-04 anticipated 114 Complete https://irct.ir/trial/4335 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A Very low Birth Weight Infants. Intervention 1: After randomization in two paralel groups , UVC will remove and a PICC will place at 3-7 days after birth in one group of the study . Using sterile technique, one specially trained neonatal nurse with cooperation of Neonatology fellowship will place the PICCs.Catheters made by Vygon company with 2 French caliber with breakable introducer needles will use. Three betadine swabs, with at least 1 min drying time for each, will be use when placing the PICCs. All PICCs will place in the upper limbs; placement of these lines will confirme at T4 to T6 level by radiograph. Trained nurses are responsible for changing the PICC dressings. The PICCs will monitore daily to ensure that the PICC dressing is occlusive. when necessary, the dressing will change. Intervention 2: In the other group after removing UVC with a clean technique, place the peripheral IV lines.