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IRCT20191002044957N1 IRCT 2020-02-11 Deputy of Research and Technology of Zahedan University of Medical Sciences Effect of probiotic mouthwash on chronic periodontitis Effect of Lactobacillus salivarius NK 02 probiotic mouthwash on mild to moderate chronic periodontitis 2019-09-23 anticipated 42 Complete https://irct.ir/trial/43175 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Forty-four patients were randomly divided into three groups (n = 14), Blinding description: Probiotic mouthwashes, chlorhexidine and normal saline mouthwashes are packaged in similar containers and labeled and coded in groups (A), (B) and (C). The codes for each container are unknown to the patient, therapist (student) and analyzer and will be kept confidential until the end of the study by the supervisor. Patients were randomly divided into three groups. 3 Chronic periodontitis. Intervention 1: Control group: 10 ml of placebo mouthwash(Normal Saline) is used twice a day for 1 minute, 30 minutes after brushing for up to 1 month. Intervention 2: Intervention group: 10 ml of probiotic mouthwash is used twice a day for 1 minute, 30 minutes after brushing for up to 1 month. Intervention 3: Intervention group: 10 ml of Chlorhexidine mouthwash is used twice a day for 1 minute, 30 minutes after brushing for up to 1 month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is lack of time and money
public Sanaz Isar
Azadegan Shargi St.
zahedan Iran (Islamic Republic of) 9817699693 +98 54 3341 5705 Faezeakbari1375555@gmail.com Zahedan University of Medical Sciences scientific Parvin Arbabi Kalati
Azadegan Shargi St.
Zahedan Iran (Islamic Republic of) 9817699693 +98 54 3244 1814 Arbabi.Parvin@zaums.ac.ir Zahedan University of Medical Sciences Iran (Islamic Republic of) Patients Referred to Periodontics Department of Zahedan Dental School, with Mild to Moderate Chronic Periodontitis The presence of envelopes between 3 and 7 mm Patient satisfaction Full public health The presence of at least 20 teeth in the mouth Lack of systemic disease (lactose intolerance, immunodeficiency disease, etc.) Lack of dry mouth Not taking any medication that affects the amount and quality of saliva No antibiotic use in the last 3 months No use of immunosuppressants in the past 6 months No smoking and other tobacco products Absence of pregnancy and lactation Non-use of other probiotic products Non-receive periodontal treatment in the last 6 months 18 years no limit Both Participant's unwillingness to continue treatment K05.3 Chronic periodontitis Placebo Treatment - Drugs Treatment - Drugs Control group: 10 ml of placebo mouthwash(Normal Saline) is used twice a day for 1 minute, 30 minutes after brushing for up to 1 month. Intervention group: 10 ml of probiotic mouthwash is used twice a day for 1 minute, 30 minutes after brushing for up to 1 month. Intervention group: 10 ml of Chlorhexidine mouthwash is used twice a day for 1 minute, 30 minutes after brushing for up to 1 month. Probing Depth. Timepoint: Immediately before us of mouthwash / one month later / three months later. Method of measurement: Measured by Williams probe. Modified Gingival Index. Timepoint: Immediately before us of mouthwash / one month later / three months later. Method of measurement: Measurement by clinical examination. Bleeding On Probing. Timepoint: Immediately before us of mouthwash / one month later / three months later. Method of measurement: Clinical observation of post-probing bleeding by Williams probe. Deputy of Research and Technology of Zahedan University of Medical Sciences Approved 2019-09-29 Ethics Committee of Zahedan University of Medical Sciences Dr. Hasabi Square, Zahedan University of Medical Sciences zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)