IRCT20191022045196N1 IRCT 2019-12-07 Shahid Beheshti University of Medical Sciences Evaluating the effect of intranasal insulin administration on motor and non-motor symptoms in Parkinson’s disease patients; a randomized double-blinded placebo-controlled clinical trial Evaluating the effect of intranasal insulin administration on motor and non-motor symptoms in Parkinson’s disease patients; a randomized double-blinded placebo-controlled clinical trial 2020-01-21 anticipated 40 Complete https://irct.ir/trial/43168 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization, Blinding description: Patients, researchers (physicians, outcome assessors) and data analysts are not aware about prescribed drugs. 2 Parkinson's disease. Intervention 1: Control group: Placebo, intranasal administration, every day, twice a day, in both sides, for 12 weeks. Intervention 2: Intervention group: Insulin, intranasal administration, 40 IU/day, every day, twice a day, in both sides, for 12 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.