IRCT20191013045092N1 IRCT 2019-11-10 Shiraz University of Medical Sciences Montelukast effect in acne treatment Comparing the efficacy of combination of doxycycline and montelukast versus doxycycline and placebo in the treatment of patients with moderate acne vulgaris referring to Shahid Faghihi hospital,1397-98 2019-11-11 anticipated 160 Complete https://irct.ir/trial/43116 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: montelukst and placebo will be put in alike boxes and by using sealed envelope online system block randomization will be done and the code of block randomization will be put on the boxes. drugs will be given to the participants monthly and the codes will not be clarified until the end of research (allocation concealment), Blinding description: informed concent will be taken from the participants and they don't know that they are recieving drug or placebo. the investigator and the care giver don't know the intervention and placebo group. 3 acne. Intervention 1: Intervention group: doxycycline (hakim company) 100 mg daily and Montelukast (abidi company) 10 mg every night + topical benzoyl peroxide 5% (pangel) on the lesions every other night for 3 months. Intervention 2: Control group: doxycycline (hakim company) 100 mg daily + topical benzoyl peroxide 5% (pangel) on the lesions every other night + placebo for 3 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is there is no further information