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IRCT20181006041252N15 IRCT 2019-10-25 Sabzevar University of Medical Sciences Effects of combined aerobic-resistance exercise training on levels of Asprosin, CTRP1, and MG53 in men with diabetes Investigating the effects of combined aerobic-resistance exercise training on levels of Asprosin, CTRP1, and MG53 in men with type 2 diabetes 2019-09-01 anticipated 25 Complete https://irct.ir/trial/42787 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be conducted based on a permutation block by a statistical consultant using random allocation software and the output sequences A and B will be available to the researcher. Accordingly, 6 blocks will be made, in each block, 2 for A treatment group, 2 for B treatment group. First, we will determine all modes in which two individuals assigned to group A and two to group B. Then we will assign one of the digits 1 to 6 to each block. In the next step, we will randomly select the order of 6 blocks. For this we will draw 6 times among cards inside a bag with replacement. For blinding the order, 24 envelopes are numbered, opaqued, sealed and stapled, respectively, and code A or B will be placed inside the envelope according to the sequence and each patient will be allocated to the group based on the letter in the envelop. 3 Type 2 diabetes. Intervention 1: Intervention group: The training group will undergo combined aerobic-resistance exercise training with distinct intensity for 12 weeks, three sessions a week. Each training session will include 5 to 10 minutes of warm-up, 45 minutes of resistance training, 30 minutes of aerobic training, respectively. In order to measure the biochemical variables, the blood sampling will be performed after 12 hours of fasting and in two steps before the start of the training program and after 12 weeks. Subjects will be asked to do no severe activity for two days prior to blood sampling. Intervention 2: Control group: control subjects also will perform their routine activities. In order to measure the biochemical variables, blood sampling will be performed after 12 hours of fasting and in two steps before the start of the training program and after 12 weeks. Subjects will be asked to do no severe activity for two days prior to blood sampling. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Dr. Mehdi Zarei
Sabzevar University of Medical Sciences, Tohid Blvd., Sabzevar Town
Sabzevar Iran (Islamic Republic of) 9617913114 +98 51 4401 1604 Zarei.m8716@yahoo.com Sabzevar University of Medical Sciences scientific Dr. Mehdi Zarei
Sabzevar University of Medical Sciences, Tohid Blvd., Sabzevar Town
Sabzevar Iran (Islamic Republic of) 9617913114 +98 51 4401 1604 Zarei.m8716@yahoo.com Sabzevar University of Medical Sciences Iran (Islamic Republic of) Lack of cardiovascular, musculoskeletal, and metabolic disorders limiting exercise Lack of high blood pressure Lack of regular exercise activity in the last 6 months Not receiving insulin No smoking Not having diabetic foot ulcers 30 years 60 years Male Inability to perform exercises E08 Diabetes mellitus due to underlying condition Treatment - Other Treatment - Other Intervention group: The training group will undergo combined aerobic-resistance exercise training with distinct intensity for 12 weeks, three sessions a week. Each training session will include 5 to 10 minutes of warm-up, 45 minutes of resistance training, 30 minutes of aerobic training, respectively. In order to measure the biochemical variables, the blood sampling will be performed after 12 hours of fasting and in two steps before the start of the training program and after 12 weeks. Subjects will be asked to do no severe activity for two days prior to blood sampling. Control group: control subjects also will perform their routine activities. In order to measure the biochemical variables, blood sampling will be performed after 12 hours of fasting and in two steps before the start of the training program and after 12 weeks. Subjects will be asked to do no severe activity for two days prior to blood sampling. Determine the levels of Asprosin. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the start of the training program. Method of measurement: Use of Luminescence quantitative and ELISA methods. Determine the levels of CTRP1. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the start of the training program. Method of measurement: Use of Luminescence quantitative and ELISA methods. Determine the levels of MG53. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the start of the training program. Method of measurement: Use of Luminescence quantitative and ELISA methods. Sabzevar University of Medical Sciences Approved 2019-11-27 Ethics committee of Sabzevar University of Medical Sciences Sabzevar University of Medical Sciences, Tohid Blvd, Sabzevar city Sabzevar Razavi Khorasan Iran (Islamic Republic of)