IRCT20120215009014N309 IRCT 2019-10-17 Hamedan University of Medical Sciences Effect of helicobacter pylori treatment versus placebo on the prevention of the recurrence of sinonasal polyps after functional endoscopic surgery Effect of helicobacter pylori treatment versus placebo on the prevention of the recurrence of sinonasal polyps after functional endoscopic surgery: a triple-blind randomized clinical trial 2018-05-22 anticipated 50 Complete https://irct.ir/trial/42763 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: The patients will be randomly assigned to intervention and control groups using block randomization. For this purpose, we will prepare four sheets of paper, writing on two sheets the name of the intervention and on the other two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are drawn. The four paper sheets will be then placed back into the container, and this action repeated until the sample size is reached, Blinding description: Patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. The analyzer will be unaware of the type of interventions. Thus, the trial will be run as triple-blind. 3 Nasal polyp. Intervention 1: Intervention group:Sinonasal polyps surgery by functional endoscopic plus nasal Fluticasone spray one puff every 12 hours, tablet Cefixime 400 mg once daily, tablet Loratadine 10 mg every 12 hours, and nasal irrigation three times daily for 2 weeks as well as Helicobacter pylori treatment with four-drug regimen including capsule Amoxicillin 1 g every 12 hours, tablet metronidazole 500 mg every 12 hours, tablet bismuth 420 mg every 12 hours, and tablet Pantoprazole 40 mg every 12 hours for 2 weeks. Intervention 2: Control group: Sinonasal polyps surgery by functional endoscopic plus nasal Fluticasone spray one puff every 12 hours, tablet Cefixime 400 mg once daily, tablet Loratadine 10 mg every 12 hours, and nasal irrigation three times daily for 2 weeks as well as tablet placebo every 12 hours for 2 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situations and the results of the study as well as approval of the financial supporting organization.