IRCT20160901029640N2 IRCT 2019-11-13 Hamedan University of Medical Sciences Steroids (Hydrocortisone), Thiamine and Ascorbic Acid Supplementation in Septic Shock The effect of Steroids (Hydrocortisone), Thiamine and Ascorbic Acid Supplementation in Septic Shock (STASIS) in hospitalized patients in intensive care unit : A Prospective, triple-blinded, Randomized, Controlled clinical trail 2019-11-22 anticipated 80 Complete https://irct.ir/trial/42615 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization (groups of 2) will be performed using random numbers list generated by Random Allocation Software © (RAS; Informer Technologies, Inc., Madrid, Spain). The numbers will be placed into sequential containers that will be kept in a secure location until allocation consignment. Enrollment and randomization will be occurred in the emergency department from available admitted ICU patients on a convenience basis. Only patients will be admitted to the ICU through the emergency department will be eligible for inclusion. The consignment will be implemented though: A person who divides patients into control and intervention groups will not be aware of the grouping of individuals, Blinding description: To ensure blinding, the allocation sequence will be kept by a different investigator than the one enrolling participants. A third investigator will be responsible for patient follow-up and assessments. Patients will not know what group they are in. Nurses, researchers, and data collectors will not be aware of patient grouping. The two intervention and control groups will not be specified for the statistician. 3 Sepsis. Intervention 1: Intervention group: Receiving three drugs hydrocortisone (50 mg, every 6 hours, 7 days or until ICU discharge), thiamine (200 mg, every 12 hours, 4 days or until ICU discharge), Ascorbic acid (1,500 mg, every 6 hours, 4 days or until ICU discharge) + Standard treatment of intensive care unit. Intervention 2: Control group: Receiving standard treatment of intensive care unit. No - There is not a plan to make this available Justification or reason for not sharing IPD is Confidentiality of information