IRCT138903094052N1 IRCT 2008-10-21 Vice chancellor for research, Tabriz University of Medical Sciences The effect of physiotherapy on symptoms of nerve entrapment syndrome The effect of neuromobilization on hand symptoms in patients with carpal tunnel syndrome 2008-10-21 anticipated 32 Complete https://irct.ir/trial/4233 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Carpal tunnel syndrome (CTS). Intervention 1: The patients in control group receive the physiotherapy routine including rest splint, TENS, and therapeutic ultrasound for 4 weeks. The patients were asked to avoid any activities that exacerbate hand symptoms. The treatment will be performed 3 days weekly. In each session, conventional TENS (80 Hz frequency, 60 microsecond pulse duration, and intensity at the level of tingling) will be used 20 minutes. Also, in each session, pulsed ultrasound (1 megahertz frequency, 1 W/cm2 intensity, and 20% duty cycle) will be used for 5 minutes. Intervention 2: The participants in group 2 (treatment group) receive the neuromobilization in addition to the physiotherapy routine mentioned in group 1 (control group). The neuromibilization will be used for 4 weeks, 3 sessions weekly. In this study, the neuromobilization includes: 1) transverse extension of the wrist accompanied by extension and radial deviation of the thumb, 2) flexor tendon gliding, and 3) the nerve mobilization by elbow flexion- extension oscillatory movement in upper limb tension test position 1. In each session, the neuromobilization will be performed 3 sets including 10 repetitions. These techniques will be performed passively by a physiotherapist.