IRCT20190718044264N1 IRCT 2022-12-03 Tehran University of Medical Sciences Effect of High Doses of intravenous Vitamin C on Coagulation Factors and Vascular endothelium in Sepsis Patients. Investigating the effect of high doses of intravenous vitamin C on coagulation factors and vascular endothelium in sepsis patients 2020-04-19 anticipated 50 Complete https://irct.ir/trial/42267 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be recorded on an Excel file by the principal investigator. Participants will be randomized via permuted block randomization. Each block will be consistent of variable sizes of 4 or 6 or 8 patients. For assignment of each patient to the drug or control group, for each patients a unique code consistent of 2 letters and a digit will be assigned. the code will be unique for each patient ( for example code AB1 for first patient). Only the principle investigator will be informed of the assignment of each code to the medication or control group, Blinding description: Patients are included in the study after obtaining consent, but patients are blinded to whether they receive only the treatment of Titarard or receive it along with the standard treatment of vitamin C. 3 Covid 19. Intervention 1: Control group: They will receive only standard treatment. Intervention 2: Intervention group: In addition to standard treatment (antibiotics, fluid therapy, etc.), they will receive 25 mg/kg of vitamin C (Vial of injectable vitamin C 500mg/5ml, Alborz Daro) as a bolus every six hours for 72 hours. Yes - There is a plan to make this available What will be shared: All data can be shared. When: The access period starts six months after the publication of the article. To whom: All researchers Conditions: for research purposes. Where to obtain: In the uploaded databases, the link will be provided to the applicants. How to obtain: Check the requester's information and then send the link. Comments: