IRCT20190917044794N1 IRCT 2019-09-28 Tabriz University of Medical Sciences Effect of synbiotic supplementation in ankylosing spondylitis Effect of synbiotic supplementation on disease activity, Th17 cells frequency, IL-23/IL-17 axis expression and serum levels of IL-17 and IL-23 in patients with ankylosing spondylitis 2019-09-23 anticipated 48 Complete https://irct.ir/trial/42188 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The selected samples will be randomly (block randomization) divided into two groups: synbiotic and placebo, Blinding description: Participants, care provider and investigator will be blind in this study. The way of participant blindness is that he will receive and use a certain number of drugs in an unnamed and labeled envelope. The way of care provider blindness is that after making diagnosis of ankylosing spondylitis to his patient and notifying his secretory, randomly gives one of the envelopes to the patient. The way of researcher's blindness is that he will not be present in the filling envelopes and selecting them by secretory. N/A Ankylosing spondylitis. Intervention 1: Intervention group: 1 synbiotic capsule fami lact per day for 3 months from Zist Takhmir factory capsuls include: 10 9 CFU bacteria namely Lactobacilus casei, Lactobacilus Ramnosis, Lactobacilus acidophilus, Lactobacillus bolgaricus, streptococus thermophillus, bifidobacterium Langom and froctooligosacharide (FOS) prebiotic. Intervention 2: Placebo group: 1 placebo capsule per day including corn starch from Zist Takhmir factory for 3 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is Abuse is possible.