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IRCT20100525004025N5 IRCT 2017-12-15 Research deputy Kermanshah University of Medical Sciences Effect of misoprostol plus isosorbide mononitrate and misoprostol plus placebo in induction of second trimester abortion Comparison of Misoprostol plus Isosorbide Mono Nitrate and Misoprostol plus placebo at the end of second trimester pregnancy. 2016-12-21 anticipated 54 Complete https://irct.ir/trial/4211 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: If patients complete Informed consent, they are divided into two intervention groups (Misoprostol +Isosorbide Mononitrate) and the placebo group (Misoprostol + Placebo) . Patients do not know the type of drug they receive. N/A Termination of pregnancy. Intervention 1: In group A(control), vitamin B6, 40 mg, is inserted into the vagina in posterior fornix, and 4 hours later, misoprostol 400mcg, equivalent to two 200mcg tablets stained with saline will be inserted . Intervention 2: In group B(case) Isosorbide Mononitrate 40 mg, is inserted into the vagina in posterior fornix, and 4 hours later, Misoprostol 400mcg stained with saline will be inserted. Undecided - It is not yet known if there will be a plan to make this available

public Dr. Mona Khorami

Kermanshah University of Medical Sciences Sorkhe Lyzheh- Imam Reza Teaching hospital-Office of Women's Education

Kermanshah Iran (Islamic Republic of) 6714415333 +98 83 3427 6301 saeedkhorami87@gmail.com Kermanshah University of Medical Sciences scientific Dr Anisodowleh Nankali

Kermanshah University of Medical Science- Sorkhe Lyzheh- Imam Reza Teaching Hospital-Office Of Women's Education

Kermanshah Iran (Islamic Republic of) 6714415333 +98 83342763018 anankali@kums.ac.ir Kermanshah university of medical sciences Iran (Islamic Republic of) Gestational age 22-13 weeks can be a condition for entering the study. nulliparous Can be a condition for entering the study. Multiparous to parity 5 Can be a condition for entering the study. singleton pregnancy can be a condition for entering the study. no limit no limit Female Women with contra indication of misoprostol (active Cardiac-pulmonary disease, Placenta Previa, history of 2 or more previous cesarean section, or history of major uterine surgeries such as myomectomy and uterine reconstruction surgery)Conditions for not admitting to study. Women with contraindication of Isosorbide mono nitrate (IMN) (sensitivity to nitrates, hypotension, hypovolemia, heart disease, significant anemia Hb below 7 gr / dl and closed angle glaucoma )Conditions for not admitting to study. XV Pregnancy with abortive outcome Placebo Treatment - Other In group A(control), vitamin B6, 40 mg, is inserted into the vagina in posterior fornix, and 4 hours later, misoprostol 400mcg, equivalent to two 200mcg tablets stained with saline will be inserted . In group B(case) Isosorbide Mononitrate 40 mg, is inserted into the vagina in posterior fornix, and 4 hours later, Misoprostol 400mcg stained with saline will be inserted. The abortion rate is 12 hours. Timepoint: 12 hours later intervention. Method of measurement: View the disposal of pregnancy products. The abortion rate is 24-12 hours. Timepoint: Abortion after 12 hours to 24 hours of intervention. Method of measurement: View the disposal of pregnancy products. Abortion rate after 24 hours. Timepoint: In the 24th hour of the intervention. Method of measurement: View the disposal of pregnancy products. Nausea. Timepoint: Every 4 hours after intervention until the Disposal of pregnancy products. Method of measurement: See Symptoms of the patient. Vomiting. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient. Diarrhea. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient. Fever and chills. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient. Headache. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient. Heart beat. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient. Confusion. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient. Research deputy Kermanshah University of Medical Sciences Approved 2016-12-14 Kermanshah University of Medical Sciences Kermanshah, Nursing Blvd, Sorkhe Lyzheh, Imam Reza Teaching Hospital, Kermanshah Kermanshah Iran (Islamic Republic of)