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IRCT20190902044673N1 IRCT 2019-11-07 Neyshabour University of Medical Sciences The effect of Atorvastatin and rosuvastatin on the Levels of 25 Hydroxyvitamin D Comparison of the effect of Atorvastatin and rosuvastatin Treatment on the Levels of 25 Hydroxyvitamin D in patient with acute coronary syndrome 2016-09-22 anticipated 80 Complete https://irct.ir/trial/42097 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we will prepare 4 leaves that are typed on the two leaves of the letter A (atrostatin) and on the other two leaves of the letter R (rosuvastatin) and draw one card for each patient, without the card being drawn. Insert. At the end of each block we have an equal number of people who received treatment A or treatment R. This process continues until the patient has been included in the study as a sample size. To make our randomization process unpredictable, we use a person (the secretary) to make this assignment and provide conditions for both the patient and the physician to determine the size of the block and the type of treatment received. Be aware and blindness will occur. If each drug contains 60 similar packages, only the letters A for atrostatin and R for rosuvastatin are written on the packaging, and only by the researcher himself. It will know the contents of the packaging and the type of medication, Blinding description: Both the patient and the physician are not aware of medications and their sequences and so blindness is occurred. 4 Patient with Acute Coronary Syndrome. Intervention 1: The first group of intervention: These patients were randomly subjected to either a single dose of 80 mg Atorvastatin as a secondary prevention treatment plus a routine treatment regimen for 8 weeks at nights. In total, 10 ml blood samples were taken at the time of admission to the emergency department; moreover, 10 ml fasting blood samples were collected within the first 24 h and 2 months after the patients were admitted to the hospital. In addition, blood samples were analyzed for biochemical parameters. Intervention 2: The second group of intervention: These patients were randomly subjected to either a single dose of 40 mg Rosuvastatin as a secondary prevention treatment plus a routine treatment regimen for 8 weeks at nights. In total, 10 ml blood samples were taken at the time of admission to the emergency department; moreover, 10 ml fasting blood samples were collected within the first 24 h and 2 months after the patients were admitted to the hospital. In addition, blood samples were analyzed for biochemical parameters. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Samaneh Tabaei
Janbazan Blvd
Neyshabur Iran (Islamic Republic of) 9315833333 +98 51 4263 2470 tabaees79@yahoo.com Neyshabour University of Medical Sciences scientific Samaneh Tabaei
Janbazan Blvd
Neyshabur Iran (Islamic Republic of) 9315833333 +98 51 4263 2470 tabaees79@yahoo.com Neyshabour University of Medical Sciences Iran (Islamic Republic of) Acute Coronary Syndrome with: chest pain, ECG ST elevation and Troponin Enzyme rising 18 years 75 years Both Diabetes Mellitus Take anti-lipid drugs during three past months I21 ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction Treatment - Drugs Treatment - Drugs The first group of intervention: These patients were randomly subjected to either a single dose of 80 mg Atorvastatin as a secondary prevention treatment plus a routine treatment regimen for 8 weeks at nights. In total, 10 ml blood samples were taken at the time of admission to the emergency department; moreover, 10 ml fasting blood samples were collected within the first 24 h and 2 months after the patients were admitted to the hospital. In addition, blood samples were analyzed for biochemical parameters. The second group of intervention: These patients were randomly subjected to either a single dose of 40 mg Rosuvastatin as a secondary prevention treatment plus a routine treatment regimen for 8 weeks at nights. In total, 10 ml blood samples were taken at the time of admission to the emergency department; moreover, 10 ml fasting blood samples were collected within the first 24 h and 2 months after the patients were admitted to the hospital. In addition, blood samples were analyzed for biochemical parameters. 25-hydroxy vitamin D level. Timepoint: At the beginning ,the first 24 hours of hospitalization, two months after admission. Method of measurement: 25-hydroxy vitamin D level in blood. Neyshabour University of Medical Sciences Approved 2016-03-09 Ethics committee of Neyshabur University of Medical Sciences Janbazan Blvd- Neyshabur Neyshabur Razavi Khorasan Iran (Islamic Republic of)