IRCT20120215009014N293 IRCT 2019-09-13 Hamedan University of Medical Sciences Effect of levetiracetam versus placebo on the clinical signs of in bipolar patients in the manic episode Effect of levetiracetam versus placebo on the clinical signs of in bipolar patients in the manic episode: a double-blind randomized clinical trial 2019-10-02 anticipated 72 Complete https://irct.ir/trial/42052 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to intervention and control groups using block randomization. For this purpose, we will prepare four sheets of paper, writing on two sheets the name of the intervention and on the other two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are drawn. The four paper sheets will be then placed back into the container, and this action repeated until the sample size is reached, Blinding description: The shape of the medications and placebos will be perfectly the same. Therefore, patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. The analyzer will be unaware of the type of interventions Thus, the trial will be run as triple blind. 2 Bipolar patients in the manic episode. Intervention 1: Intervention group: Standard treatment plus tablet levetiracetam 250 mg three times daily for 28 days. Intervention 2: Control group: Standard treatment plus tablet placebo three times daily for 28 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situations and the results of the study as well as approval of the financial supporting organization.