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IRCT20190830044645N1 IRCT 2019-10-01 Iran University of Medical Sciences ŁEfficacy of oral Probiotic with Doxycyclin in comparison with Doxycyclin in Acne Vulgaris efficacy of oral probiotic with doxycyclin in comparison with doxycyclin in acne vulgaris 2018-07-23 anticipated 80 Complete https://irct.ir/trial/41960 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients enter the treatment groups on a 1: 1 ratio using Excel software. From a box with 100 sealed envelopes, each patient is selected with one envelope containing either A or B. (Method I: A and Method II: B), Blinding description: just the principle investigator knows about patient and no one else dont know about any code or treatment plan. Patients in the intervention and control groups did not know which treatment group they entered. These patients are not aware of the type of treatment group that they enter. Both groups receive standard and identical treatment. The intervention group uses probiotic capsule in addition to standard treatment. The control group received only standard treatment. 2-3 Acne Vulgaris. Intervention 1: Intervention group: patients will treat with antibacterial shampoo and Adapalen cream as uniform topical treatment. The intervention group receive doxycycline capsule plus probiotic capsule daily. All of patients acne lesions will photographed with digital camera before treatment and one , two and three months after treatments. treatment response will assess with global acne grading and acne severity index. Intervention 2: Control group:patients will treat with antibacterial shampoo and Adapalen cream as uniform topical treatment. control group receive only doxycycline capsule dailyand do not receive d probiotic capsule. All of patients acne lesions will photographed with digital camera before treatment and one , two and three months after treatments. treatment response will assess with global acne grading and acne severity index. Yes - There is a plan to make this available What will be shared: all collected deidentified IPD to be shared When: starting after publication To whom: our data is available for researchers. Conditions: data for analysis and usage in research programs can be use , but he should confirm the data is belong to us. Where to obtain: contact email : mohamadi11248@gmail.com How to obtain: after one week he receive data Comments:
public Masoumeh Mohamadi
Rasool akram hospital
Tehran Iran (Islamic Republic of) 1469935947 +98 21 4445 3955 mohamadi11248@gmail.com Iran University of Medical Sciences scientific Masoumeh Mohamadi
Rasool akram hospital
Tehran Iran (Islamic Republic of) 1469935947 +98 21 4445 3955 mohamadi11248@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) Patient with Moderate acne (grade 2 or 3 of global acne assessment scale with totally 20 to 50 inflammatory lesion ) people with age between 18 to 35 18 years 35 years Both Pregnant or Breast feeding female patient Receiving antibiotics in last months Patient with dyspepsia L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: patients will treat with antibacterial shampoo and Adapalen cream as uniform topical treatment. The intervention group receive doxycycline capsule plus probiotic capsule daily. All of patients acne lesions will photographed with digital camera before treatment and one , two and three months after treatments. treatment response will assess with global acne grading and acne severity index Control group:patients will treat with antibacterial shampoo and Adapalen cream as uniform topical treatment. control group receive only doxycycline capsule dailyand do not receive d probiotic capsule. All of patients acne lesions will photographed with digital camera before treatment and one , two and three months after treatments. treatment response will assess with global acne grading and acne severity index Acne grading in global acne grading and acne severity index. Timepoint: before intervention, one , two and three months after treatment. Method of measurement: global acne grading and acne severity index. Iran University of Medical Sciences Approved 2019-03-09 Iran University of Medical Sciences Ethics Committee Satarkhan street , Niyayesh Avenue , Rasool Akram hospital , Dermatology Department Office Tehran Tehran Iran (Islamic Republic of)