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IRCT201703194010N18 IRCT 2017-10-13 Shahid Beheshti University of Medical Sciences, National Nutrition and Food Technology Research investigate effect of citrulline in the treatment of non-alcoholic fatty liver The effect of citrulline supplementation on serum lipids, liver enzymes, inflammatory markers and hepatic steatosis in patient with nonalcoholic fatty liver disease 2017-04-04 anticipated 50 Complete https://irct.ir/trial/4196 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A non alcoholic fatty liver disease. Intervention 1: intervention group:2 gram citrulline per day for three months. Intervention 2: placebo group:2 gram starche per day for three months.
public Azita Hekmatdoust
West arghavan, Sanaat square, Farahzadi boulvard, Shahrake gharb
Tehran Iran (Islamic Republic of) +98 21 2235 7483 a_HEKMAT2000@YAHOO.COM National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sci scientific Azita Hekmatdoust
West arghavan, Sanaat square, Farahzadi boulvard, Shahrake gharb
Tehran Iran (Islamic Republic of) +98 21 2235 7483 a_hekmat2000@yahoo.com National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sci Iran (Islamic Republic of) Inclusion criteria for the study: Age 18 and older;Concentrations of liver enzymes ALT and AST greater than 1.5 times normal;Evidence of nonalcoholic steatohepatitis in Fibroscan (Controlled Attenuation Parameter (CAP) score> 263);Have not a history of consumption alcohol more than 10 milligrams of per day for women and more than 20 mg per day for men;Not consume any dietary supplement in the past three months not consume any hepatotoxic drugs such as phenytoin, lithium Exclusion criteria: Not continue to cooperation;Biliary diseases; autoimmune and cancer and inherited disorders affecting liver during the study;Those less than 10% supplemen at the end of the sixth and twelth week consume. no limit no limit Both (K75.8) Other specified inflammatory liver diseases Treatment - Other Other intervention group:2 gram citrulline per day for three months placebo group:2 gram starche per day for three months LDL-C. Timepoint: Being andend of intervention. Method of measurement: Enzymatic methods using kits. HDL-C. Timepoint: Being andend of intervention. Method of measurement: Enzymatic methods using kits. TG. Timepoint: Being andend of intervention. Method of measurement: Enzymatic methods using kits. Total Cholesterol. Timepoint: Being andend of intervention. Method of measurement: Enzymatic methods using kits. FBS. Timepoint: Being andend of intervention. Method of measurement: Enzymatic methods using kits. Fasting insulin. Timepoint: Being andend of intervention. Method of measurement: Radioimmunoassay µU/mL. AST. Timepoint: Being andend of intervention. Method of measurement: Enzymatic methods using kits. ALT. Timepoint: Being andend of intervention. Method of measurement: Enzymatic methods using kits µg/m. HOMA. Timepoint: Being andend of intervention. Method of measurement: Calculation. TNF-α. Timepoint: Being andend of intervention. Method of measurement: Elisa Pg/dl. IL_6. Timepoint: Being andend of intervention. Method of measurement: Elisa Pg/dl. Steatosis. Timepoint: Being andend of intervention. Method of measurement: Ultrasonography Grade 0: absence of steatosis grade 1: mild steatosis grade 2: moderate steatosis grade 3: severe steatosis. Total energy intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire Kcal per day. Carbohydrate intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire gram per day. Protein intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire gram per day. Total fat intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire gram per day. SAFA intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire gram per day. PUFA intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire gram per day. MUFA intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire gram per day. Total fiber intake. Timepoint: Beginning and end of intervention. Method of measurement: questionnaire gram per day. Colorectal Research Center,IRAN University of Medical Sciences Shahid Beheshti University of Medical Sciences, National Nutrition and Food Technology Research Colorectal Research Center,IRAN University of Medical Sciences Approved 2017-03-06 National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sci West arghavan, Sanaat square, Farahzadi boulvard, Shahrake gharb Tehran Iran (Islamic Republic of)