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IRCT20160110025929N28 IRCT 2019-09-28 Hamedan University of Medical Sciences Comparison the effect of sodium bicarbonate and zinc chloride mouth washes on incidence and severity of oral mucositis Comparison the effect of sodium bicarbonate and zinc chloride mouth washes on incidence and severity of oral mucositis in patients with cancer under chemotherapy 2019-09-23 anticipated 144 Complete https://irct.ir/trial/41838 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: For random allocation of samples in three groups, 6 blocks will be used as random block allocation. For this purpose, 20 modes of 6-block are written on pieces of paper and put in envelopes and randomly replaced. Patients will be assigned to the intervention or control groups according to the order of the letters of the blocks removed. N/A Oral mucositis. Intervention 1: Intervention group(1): patients receive 5% sodium bicarbonate solution every 8 hours, 2 times for 21 days. Intervention 2: Intervention group(2): patients will receive 0.5% zinc chloride solution every 8 hours, 2 times for 21 days. Intervention 3: Control group(placebo): patients will receive 2 cc placebo (distilled water) every 8 hours, 2 time for 21 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Fatemeh Mohamadi
Shahid Fahmideh St., Hamadan University of Medical Sciences, Hamadan
Hamadan Iran (Islamic Republic of) 38698-65178 +98 81 3838 0535 f.Mohammadi@umsha.ac.ir Hamedan University of Medical Sciences scientific Fatemeh Mohamadi
Shahid Fahmideh St., Hamadan University of Medical Sciences, Hamadan
Hamadan Iran (Islamic Republic of) 38698-65178 +98 81 3838 0535 f.Mohammadi@umsha.ac.ir Hamedan University of Medical Sciences Iran (Islamic Republic of) Patients with cancer aged 18 to 65 years Cancer stage 1 or 2 Absence of oral ulcers No sensitivity to zinc chloride and sodium bicarbonate 18 years 65 years Both Absence on at least one day from the days designated for follow-up Dissatisfaction with continuing to participate in the study K12.3 Oral mucositis (ulcerative) N/A N/A N/A Intervention group(1): patients receive 5% sodium bicarbonate solution every 8 hours, 2 times for 21 days. Intervention group(2): patients will receive 0.5% zinc chloride solution every 8 hours, 2 times for 21 days. Control group(placebo): patients will receive 2 cc placebo (distilled water) every 8 hours, 2 time for 21 days. Incidence and severity of oral mucositis. Timepoint: Before and up to twenty days after the intervention. Method of measurement: World Health Organization Mucositis Scale. Deputy of research and technology Approved 2019-07-20 Ethics Committee of Hamadan University of Medical Sciences Shahid Fahmideh St., Hamadan University of Medical Sciences, Hamadan Hamadan Hamadan Iran (Islamic Republic of)