<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20190831044649N1</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2019-09-13</date_registration>
      <primary_sponsor>Payame noor university</primary_sponsor>
      <public_title>The Effect of One Bout of Continuous Aerobic Exercise against Interval on ICAM-1 and VCAM-1 Plasma Levels in Patients with Coronary Artery Disease</public_title>
      <acronym></acronym>
      <scientific_title>The Effect of One Bout of Continuous Aerobic Exercise against Interval on ICAM-1 and VCAM-1 Plasma Levels in Patients with Coronary Artery Disease</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2019-09-07</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>9</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/41824</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Education/Guidance.</study_design>
      <phase>N/A</phase>
      <hc_freetext>Coronary artery disease.</hc_freetext>
      <i_freetext>After selecting the subjects, a full explanation of the goals, benefits of the exercise, and a written consent form, medical history and physical activity readiness questionnaire (PAR_Q) were completed. In order to eliminate the possible differences of the study group, the study was cross-sectional and voluntary. The first session of the program introduced the equipment and training methods. Subjects were asked to avoid physical activity and any physical stimuli (eg caffeine, tobacco, and alcohol) 48 hours prior to exercise. They were also asked not to eat for 2 hours before exercise (drinking water was allowed). The exercise test was performed according to the modified Bruce protocol and performed on a treadmill and electrocardiogram of COSMED 200 (COSMED), Italy. The test was stopped by observing one of the symptoms of abnormal electrocardiography, the Borg 17 pressure scale, and the plateau heart rate. After 72 hours, the subjects were randomly assigned to a single-week aerobic interval training protocol. Continuous activity was performed by running or walking for 30 minutes at 60% intensity of the plateau heart rate. Periodic activity also included 30 minutes of walking or running with varying intensities between 50% (2 minutes) and 80% (1 minute) of the plateau heart rate and with a mean workload of 60% of the reserve heart rate..</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>Yes - There is a plan to make this available</results_IPD_plan>
      <results_IPD_description>What will be shared:
The results of the study are provided to the samples.

When:
3 months after the article was published

To whom:
Subjects

Conditions:
For further research

Where to obtain:
Researcher -Payame noor university

How to obtain:
It takes about 2 weeks.

Comments:
</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Ali Barzegari</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Nakhl St, Lashkarak Highway, Tehran</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>469719395</zip>
        <telephone>+98 21 2332 0000</telephone>
        <email>ali_barzegari@pnu.ac.ir</email>
        <affiliation>Payame noor university</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Ali Barzegari</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Nakhl St, Lashkarak Highway, Tehran</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>4697-19395</zip>
        <telephone>+98 21 2332 0000</telephone>
        <email>ali_barzegari@pnu.ac.ir</email>
        <affiliation>Payame noor university</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Known coronary artery disease (based on medical records)
Having over 60 years old
Failure to exercise test
History of angiography
History of CCU admission
No record of regular physical activity during the three months prior to the intervention</inclusion_criteria>
      <agemin>61 years</agemin>
      <agemax>65 years</agemax>
      <gender>Female</gender>
      <exclusion_criteria>healthy people
Patients with a history of using pacemaker stabilized blood failure
Head injury history in the last six months
Myocardial infarction
history of other diseases</exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>I25.1</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Atherosclerotic heart disease</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Treatment - Other</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>After selecting the subjects, a full explanation of the goals, benefits of the exercise, and a written consent form, medical history and physical activity readiness questionnaire (PAR_Q) were completed. In order to eliminate the possible differences of the study group, the study was cross-sectional and voluntary. The first session of the program introduced the equipment and training methods. Subjects were asked to avoid physical activity and any physical stimuli (eg caffeine, tobacco, and alcohol) 48 hours prior to exercise. They were also asked not to eat for 2 hours before exercise (drinking water was allowed). The exercise test was performed according to the modified Bruce protocol and performed on a treadmill and electrocardiogram of COSMED 200 (COSMED), Italy. The test was stopped by observing one of the symptoms of abnormal electrocardiography, the Borg 17 pressure scale, and the plateau heart rate. After 72 hours, the subjects were randomly assigned to a single-week aerobic interval training protocol. Continuous activity was performed by running or walking for 30 minutes at 60% intensity of the plateau heart rate. Periodic activity also included 30 minutes of walking or running with varying intensities between 50% (2 minutes) and 80% (1 minute) of the plateau heart rate and with a mean workload of 60% of the reserve heart rate.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>New indices ICAM-1 (Intercellular Adhesion Molecule 1). Timepoint: Before and after the training protocols. Method of measurement: Enzyme-linked Immunosorbent Assay.</prim_outcome>
      <prim_outcome>VCAM-1 (Vascular cell adhesion molecule-1). Timepoint: Before and after the training protocols. Method of measurement: Enzyme-linked Immunosorbent Assay.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome></sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Payame noor university</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2018-12-29</approval_date>
        <contact_name>Ethics committee of payame noor university</contact_name>
        <contact_address>Department of physical education and sport, Payame Noor University, PO BOX 19395-3697, Tehran, IRAN تهران Alborz Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
