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IRCT20100102002954N16 IRCT 2019-09-15 Shahroud University of Medical Sciences Comparison of the efficacy of Azithromycin and Doxycycline in treatment of acne Comparison of the efficacy of Azithromycin and Doxycycline in cases of moderate intensity inflammatory papulopustular acne, a randomized clinical trial 2019-09-06 anticipated 140 Complete https://irct.ir/trial/41681 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization was done using permuted block randomization method using blocked random allocation syntax in SPSS software. For calculation sample size, number of blocks and block size was determined. Block size was 4. Allocation concealment was done using closed opaque envelope. 3 Acne conglobata. Intervention 1: Intervention group: Using Azithromysin tablet (Pars darou Company) in a single dose (250 mg/day) orally for three months in addition using topical Tertinoin lotion 0.05% (Alborz company) twice a day (10 drops per 12 hours, locally) for three months. Intervention 2: Control group: Using of a Doxycycline capsule (Pars Darou company) twice a day orally (total 200 mg/ daily) in addition to topical Tertinoin lotion 0.05% (Alborz company) twice a day (10 drops per 12 hours, locally) for three months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After completing the research and summarizing the results, it will be decided.
public Dr.Mohammad Bagher Sohrabi
Imam Hossein Hospital, End Imam street, Shahroud, Iran.
Shahroud Iran (Islamic Republic of) 3616611151 +98 23 3234 2000 mb.sohrabi@shmu.ac.ir Shahroud University of Medical Sciences scientific Dr. Marjan Talebi
Imam Hossein hospital., End Imam street., Shahroud., Iran
Shahroud Iran (Islamic Republic of) 3616611151 +98 23 3234 2000 m_talebi@gmail.com Shahroud University of Medical Sciences Iran (Islamic Republic of) Patients with moderate inflammatory papulopustular acne, Age range 15-50 years, Satisfaction with the research. 15 years 50 years Both Previous burns, Severe hormonal disorders such as hypothyroidism, Chronic liver and kidney disease, Pregnancy and lactation, doing restorative skin care like laser L70.1 Acne conglobata Treatment - Drugs Treatment - Drugs Intervention group: Using Azithromysin tablet (Pars darou Company) in a single dose (250 mg/day) orally for three months in addition using topical Tertinoin lotion 0.05% (Alborz company) twice a day (10 drops per 12 hours, locally) for three months. Control group: Using of a Doxycycline capsule (Pars Darou company) twice a day orally (total 200 mg/ daily) in addition to topical Tertinoin lotion 0.05% (Alborz company) twice a day (10 drops per 12 hours, locally) for three months. Acne healing speed. Timepoint: Once every two weeks. Method of measurement: Skin imaging and global response assessment. Vice chancellor for research; Shahroud University medical and Sciences Approved 2017-08-31 Ethics committee of Shahroud University of Medical Sciences Shahroud University of Medical Sciences; 7 Tir squer, Shahroud Shahroud Semnan Iran (Islamic Republic of)