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IRCT201501213989N1 IRCT 2016-01-03 Vice chancellor for research,Ardabil University of Medical Sciences Tetanus-diphtheria(Td) vaccine effect on recurrent minor oral aphthous. Tetanus diphtheria(Td) booster vaccine effect on recovery and relapse of recurrent minor oral aph Tetanus diphtheria(Td) booster vaccine effect on recovery and relapse of recurrent minor oral aphthous. 2015-02-20 anticipated 80 Complete https://irct.ir/trial/4161 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Patients are not aware of the content of what they injected . The nurse injected the drug is not aware of its content. Tracking the effectiveness of treatment is not aware of the type of treatment. Statistician is unaware of the content of the treatment groups. N/A Recurrent Aphthous stomatitis( minor). Intervention 1: In the intervention group, one mg of oral colchicine daily for 5 days plus a booster dose of ,Tetanus diphtheria(Td) vaccine is injected right deltoid region. In case of recurrent aphthous, oral colchicine one mg daily for 5 days ,repeated. Intervention 2: In the control group one milligram oral colchicine daily for five days plus a half cc of vitamin B6 as a placebo in right deltoid area injected. In case of recurrent aphthous, oral colchicine one mg daily for 5 days ,repeated.
public Sharam Habibzadeh
Unit3,No 31,Alley Resalat3,Street 13 Aban
Ardabil Iran (Islamic Republic of) 5619814398 +98 45 3351 4390 s.habibzadeh@arums.ac.ir ,shahramhabibzadeh@yahoo.com Ardabil University of Medical science(ARUMS) scientific Shahram Habibzadeh
Kousar Minisity,Daneshghah Street,Ardabil
Ardabil Iran (Islamic Republic of) 5618985991 +98 45 3352 2391 research ARUMS(Ardabil University of Medical Science) Iran (Islamic Republic of) Inclusion criteria: 20 to 60 years old patients; who have 1 to 3 minor(1-8 millimeters) oral aphthous; with at least one relapse per month, Exclusion criteria :establishment of anemia; HIV or Behcet's syndrome ; recipients of tetanus-diphtheria(Td) vaccine in the last five years 20 years 60 years Both K12.0 Recurrent oral aphthae Treatment - Drugs Treatment - Drugs In the intervention group, one mg of oral colchicine daily for 5 days plus a booster dose of ,Tetanus diphtheria(Td) vaccine is injected right deltoid region. In case of recurrent aphthous, oral colchicine one mg daily for 5 days ,repeated. In the control group one milligram oral colchicine daily for five days plus a half cc of vitamin B6 as a placebo in right deltoid area injected. In case of recurrent aphthous, oral colchicine one mg daily for 5 days ,repeated. Aphthous remission after treatment. Timepoint: At the beginning and end of the study. Method of measurement: Based on the judgment of those who have studied .Complete remission, partial remission, non-recovery. The interval between the occurrence of aphthous. Timepoint: 180 days. Method of measurement: One day(24 hours). The number of aphthous in each recurrence. Timepoint: 180 days. Method of measurement: The number of aphthous. Measuring pain intensity. Timepoint: 180 days. Method of measurement: A score of 0 to ten according to one's own judgment. Size of aphthous. Timepoint: 180 days. Method of measurement: milimeter. Injection site reactions. Timepoint: Fifteen days after injection. Method of measurement: Physical examination in case of complications. Vice chancellor for research,Ardabil University of Medical Sciences Approved 2014-10-18 Ethics committee of Ardabil University of Medical Science Kousar Minisity,Daneshghah Street,Ardabil Ardabil Iran (Islamic Republic of)