]>
IRCT20190409043207N2 IRCT 2019-10-22 Yazd University of Medical Sciences Comparison of the oocyte quality in patients with poor ovarian response undergone two triggering methods. Comparison of two methods of double- trigger (GNRHa+HCG) and HCG-trigger on the final oocyte maturation in poor responder patients. 2019-09-06 anticipated 122 Complete https://irct.ir/trial/41606 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: For randomization selection of the patients, through the site www. randomization.ir, we create a list of random numbers for assigning patients to treatment groups (A&B). Then, the number of each patient, which is according to the entrance number to the clinic, is written on the envelope, and the type of treatment that was randomly selected through the mentioned site is put in the envelope. Also, thick envelopes are used in the aim to not be identifiable, the type of treatment for each patient, in the envelope, by the people who make the random assignment of the patient. In this way, each patient, who refer for giving treatment, comes with an envelope containing the type of assigned treatment. 3 Infertility. Intervention 1: Intervention group: Intervention group: Trigger with 0.2 mg deca peptil ampoule and 10000 HCG ampoule 40 and 34 hours before oocyte retrieval. Intervention 2: Intervention group: Trigger by standard method with 10000units HCG 36 hours before oocyte retrieval. Yes - There is a plan to make this available What will be shared: All data obtained from this study will be released after being unidentified studies participants When: Get started 6 months after publishing the study results To whom: The findings of this study will be accessible for all individuals Conditions: To improve pregnancy outcomes of the infertility centers Where to obtain: Yazd Research and Clinical Center for Infertility How to obtain: Receiving the author's confirmation and obtaining approval from the director of the Yazd Infertility Clinic Comments:
public Dr maryam Mortazavi
Bu Ali Ave, Safaeieh
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 8119 m_mortazavi58@yahoo.com Yazd University of Medical Sciences scientific Dr Maryam Mortazavi
Bu Ali Ave- Safaeieh
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 8119 m_mortazavi58@yahoo.com Yazd University of Medical Sciences Iran (Islamic Republic of) Age more than 40 years or other risk factors for poor ovarian response. Less than three oocytes in the previous IVF cycle Abnormal ovarian reserve test Two histories of poor ovarian response following receiving maximal stimulation 18 years 50 years Female Severe male factor Untreated endocrine disorders Severe uterine anomaly N98.9 Complication associated with artificial fertilization, unspecified Treatment - Drugs Treatment - Drugs Intervention group: Intervention group: Trigger with 0.2 mg deca peptil ampoule and 10000 HCG ampoule 40 and 34 hours before oocyte retrieval. Intervention group: Trigger by standard method with 10000units HCG 36 hours before oocyte retrieval. Clinical pregnancy rate. Timepoint: Four weeks after positive beta hCG. Method of measurement: Fetal heart activity by trans-vaginal ultrasonography. Biochemical pregnancy rate. Timepoint: 14 days after embryo transfer. Method of measurement: Positive B-HCG. Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: It is defined as the numbers of gestational sacs that detected throughout sonography per number of embryos transferred (100 embryo). Abortion rate. Timepoint: Before 20th weeks of gestation. Method of measurement: Observation and counting. COC counting. Timepoint: The day of oocyte puncture. Method of measurement: Counting. MII oocyte number. Timepoint: The day of puncture. Method of measurement: Counting. 2PN number. Timepoint: 1 day after fertilization. Method of measurement: Counting. Estradiol level. Timepoint: In the day of hCG injection. Method of measurement: Biochemical measurements in the blood. Embryo grading. Timepoint: 3 days after puncture. Method of measurement: Observation and grading according to the embryo references. Yazd University of Medical Sciences Approved 2019-07-28 Ethics Committee of Shahid Sadoughi University of Medical Sciences Bouali Ave, Safayeh. Yazd Yazd Iran (Islamic Republic of)