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IRCT20190409043207N3 IRCT 2019-12-22 Yazd University of Medical Sciences Comparison of two methods of double- trigger(GNRHa+HCG) and HCG-trigger on final oocyte maturation in normal responder patients. Comparison of two methods of double- trigger(GNRHa+HCG) and HCG-trigger on final oocyte maturation in normal responder patients. 2019-09-06 anticipated 130 Complete https://irct.ir/trial/41602 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The sampling method was simple randomization, so this method is based on a random number table. Thus, we assign 65 odd number to the case group and 65 even number to the control group. The patient randomly assigned to the one group by selecting one number, Blinding description: This study is double blind. The participant know abot study design but are blind and don't aware from grouping. Data analysor don't knows the groups as A and B and is unaware of type of treatment in each group.(double blind). 2 Infertility. Intervention 1: Intervention group: Trigger with 0.2 mg deca peptil ampoule and 6500 HCG ampoule 40 and 34 hours before oocyte retriveal. Intervention 2: Intervention group: Trigger by standard method with 6500 units HCG 36 hours beforeo oocyte retriveal. Yes - There is a plan to make this available What will be shared: All data obtained from this study will be released after being unidentified studies participants. When: Get started 6 months after publishing study results To whom: The findings of this study will be accessible to all individuals. Conditions: To improve pregnancy outcomes in infertility clinics Where to obtain: Yazd Research and Clinical Center for Infertility How to obtain: Receiving the author's confirmation and obtaining approval from the director of the Yazd Infertility Clinic Comments:
public Dr maryam Mortazavi
Bu ali Ave- Safaeieh
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 8119 m_mortazavi58@yahoo.com Yazd University of Medical Sciences scientific دكتر مريم مرتضوي
Bu ali Ave- Safaeieh
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 8119 m_mortazavi58@yahoo.com Yazd University of Medical Sciences Iran (Islamic Republic of) normal responder women Age less than 42 years BMI <30 Kg / m2 Estradiol Trigger Doses between 500 and 3000 pg / ml 18 years 42 years Female Severe male factor Untreated thyroid disorders Severe uterine anomaly Existence of pco criteria FSH> 10 days of the third menstrual cycle and AMH <1 BMI less than 18 and more than 35 Predicting the the chance of of ovarian hyper stimulation syndrom(OHSS) Hyperprolactinemia Endocrine Disorders Congenital adrenal hyperplasia N98.9 Complication associated with artificial fertilization, unspecified Treatment - Drugs Treatment - Drugs Intervention group: Trigger with 0.2 mg deca peptil ampoule and 6500 HCG ampoule 40 and 34 hours before oocyte retriveal. Intervention group: Trigger by standard method with 6500 units HCG 36 hours beforeo oocyte retriveal. Number of follicles. Timepoint: From the tenth day of the cycle. Method of measurement: sonography. Number of recovered oocytes. Timepoint: Oocyte recovery day. Method of measurement: observation. Number of canceled cycles. Timepoint: Oocyte recovery day. Method of measurement: observation. Number of embryo. Timepoint: 2 days after Oocyte recovery. Method of measurement: observation. Embryo grading. Timepoint: 3 days after Oocyte recovery. Method of measurement: observation. Number of transfered embryo. Timepoint: embryo transfere day. Method of measurement: observation. Chemical pregnancy rate. Timepoint: 14 days after embryo transfer. Method of measurement: positive B-HCG. Clinical pregnancy rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: fetal heart rate in sonography. Yazd University of Medical Sciences Approved 2019-07-28 SShahid Sadoughi University of Medical Sciences Bouali Ave, Safayeh. Yazd Yazd Iran (Islamic Republic of)