IRCT20190710044171N1 IRCT 2020-09-08 Mazandaran universit of medical sciences comparison gene expression pattern in blood sample of patients with major depressive disorder Comparison of gene expression pattern in blood sample of depressed patients treated with fluoxetine and cognitive-behavioral therapy 2020-06-09 anticipated 40 Complete https://irct.ir/trial/41601 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients with MDD disorder are identified by a physician based on the DSM-V criteria. The degree of depression of patients is determined by self-assessment based on the Beck questionnaire. Patients are randomly divided into two groups according to Graphpad online software: CBT (intervention) therapies are divided, Blinding description: Cognitive-behavioral group therapy is the study of the blind study group. 3 major depressive disorder. Intervention 1: Intervention group: The group receiving 12 sessions of cognitive-behavioral therapy is a group that psychotherapists use to educate people and change their feelings and behaviors through their thought patterns and beliefs. Each session lasts 90 minutes. Control group: Drug therapy group in which patients take 20 mg of fluoxetine daily for 3 months. Intervention 2: Control group: Control group: In the drug therapy group, patients receive 20 mg of fluoxetine daily for three months. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information