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IRCT20190805044444N1 IRCT 2019-09-12 Shoushtar Faculty of Medical Sciences The effect of vaginal cream zizyphus spina(sider) leave in the treatment of candidacies vulvovaginitis. Comparison of the effect of vaginal cream of zizyphus spina (sider) leave with clotrimazole vaginal cream on treatment of candidiasis vulvovaginitis 2019-09-10 anticipated 96 Complete https://irct.ir/trial/41442 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Samples were randomly divided into permutation blocks with the size of block 6. The drugs used in this study were randomly assigned by the out-of-study list to the corresponding codes in the closed envelopes and then assigned to each patient who entered the study, Blinding description: Ziziphus spina-christi green leaves vaginal cream was prepared by adding the extract to a suitable cream base (emulsion of water in oil) at concentrations of 5% . In the pharmacy, 1% of clotrimazole vaginal cream was prepared using the same base. All final products had the same appearance and an approved color was used to maintain uniformity. Microbiological and physicochemical tests (uniformity, physical stability, distribution, and acidity) were performed on the prepared formulations. Samples will be randomly assigned to A and B medication. Both Ziziphus spina-christi leaves vaginal cream and clotrimazole 1% can be used with applicators and are named A and B because the researcher and research units are unaware of them. N/A candidacies vulvovaginitis. Intervention 1: Intervention group:vaginal cream of zizyphus spina (sider) leave once applicator a day for 1 week. Intervention 2: Control group: Clotrimazole vaginal cream once applicator a day for 1 week. Yes - There is a plan to make this available What will be shared: The part of the data includes information about the main consequences or the like it is possible to share When: Start the access period 12 months after printing the results To whom: Only for researchers working in academic and scientific institutions will be available Conditions: The data was used to check fungal infections in other parts of the body. Where to obtain: By receiving the email of the responsible author at honarmandpour.a@gmail.com How to obtain: After requesting data by email, the data will be sent within 1-2 weeks Comments:
public Azam Honarmandpour
Shoushtar Faculty of Medical Sciences, Alhadi Hospital, Rajaie BLV
Shoushtar Iran (Islamic Republic of) 6451684534 +98 61 3622 9544 navarbaf_n@ajums.ac.ir Shoushtar Faculty of Medical Sciences scientific Azam Honarmandpour
Shoushtar Faculty of Medical Sciences, Alhadi Hospital, Rajaie BLV
Shoushtar Iran (Islamic Republic of) 6451684534 +98 61 3622 9544 navarbaf_n@ajums.ac.ir Shoushtar Faculty of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Candidate vaginitis signs and symptoms in interview or observation and confirmation by laboratory study; married women between 20-45 years old; patients who had a single sexual partner and they themselves were the only sexual partner of their respective spouse; Informed consent to participate in the study. 20 years 45 years Female Exclusion criteria: women who had used oral or topical antifungal drugs, corticosteroids and antibiotics 2 weeks before the study; Steroid medication use; IUD use; pregnancy; breast feeding; diabetes and immunodeficiency; Abnormal uterine bleeding; menstruation and side effects of the drug. B37.3 Candidiasis of vulva and vagina Treatment - Drugs Treatment - Drugs Intervention group:vaginal cream of zizyphus spina (sider) leave once applicator a day for 1 week Control group: Clotrimazole vaginal cream once applicator a day for 1 week Compelet remission. Timepoint: 7days and 14 days after treatment. Method of measurement: Evaluation of clinical symptom's remission with questionnaire. Vaginal Culture Results. Timepoint: Before and 7 Day After intervention. Method of measurement: Esmear Vaginal. Vaginal pH. Timepoint: Before and 7 day After intervention. Method of measurement: By pH meter strips. Shoushtar Faculty of Medical Sciences Approved 2019-07-10 Ethics committee of shoushtar faculty of medical sciences Shoushtar Faculty of Medical Sciences, Alhade hospital, Rajae BLV, Shoushtar shoushtar Khouzestan Iran (Islamic Republic of)