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IRCT20190721044288N1 IRCT 2020-10-27 Birjand University of Medical Sciences Effect of vitramin D in asthma The effect of vitamin D on pulmonary function and serum level of interleukin 10 and antioxidant activity in patient with moderate to severe asthma. 2019-04-19 anticipated 60 Complete https://irct.ir/trial/41052 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Simple random lottery method, Blinding description: Study participants were not aware of the drug used. The control group also received placebo of the same shape, color and size as the intervention group drug. The outcome assessor (co-nurse) assessed the outcome without informing the patient group. 3 Asthma. Intervention 1: Control group: received 1 pearl containing glucose daily (made by Birjand School of Pharmacy) as a placebo for 3 months. Intervention 2: Intervention group: received 1 unit of pearl vitamin D 2000 units (manufactured by Dana Pharmaceutical Company) daily for 3 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is There are no plans to publish it
public Zabihullah Mohaghegh
Moallem Str
Birjand Iran (Islamic Republic of) 9717811674 +98 56 3232 3232 oabstudent@gmail.com Birjand University of Medical Sciences scientific Dr. Gholamreza Mortazavimoghaddam
Ghaffari Str
Birjand Iran (Islamic Republic of) 9717811674 +98 56 3232 3232 oabstudent@gmail.com Birjand University of Medical Sciences Iran (Islamic Republic of) moderate to severe asthma treated with inhaled corticosteroid (ICS) vitamin D deficiency No systemic disease No diabetes No infectious disease No liver disease No heart disease No kidney disease 16 years no limit Both patient expired patient who do not use his drug add new systemic disease change of treatment Patients taking antioxidant drugs Use of any medication that affects the mitochondrial system and antioxidant storage J45 Asthma Placebo Prevention Control group: received 1 pearl containing glucose daily (made by Birjand School of Pharmacy) as a placebo for 3 months. Intervention group: received 1 unit of pearl vitamin D 2000 units (manufactured by Dana Pharmaceutical Company) daily for 3 months. Serum levels of antioxidants in the blood serum of patients. Timepoint: Measurement of serum antioxidant levels at the beginning of the study and 3 months after starting vitamin D intake. Method of measurement: Use of thiobarbituric acid method. Serum levels of interleukin 10 in the blood serum of patients. Timepoint: Measurement of serum interleukin level 10 at the beginning of the study and 3 months after starting vitamin D intake. Method of measurement: Using the commercial kit by ELISA method. Birjand University of Medical Sciences Approved 2018-10-29 Ethics Committee of Birjand University of Medical Sciences Ghaffari Str Birjand South Khorasan Iran (Islamic Republic of)