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IRCT20190721044285N1 IRCT 2019-07-31 Tehran University of Medical Sciences Effect of Ephedrine and Ketamine on onset time of Atracurium Comparison of the effects of Ephedrine and Ketamine with Placebo on onset time of Atracurium in patients under general anesthesia 2019-08-06 anticipated 141 Complete https://irct.ir/trial/41032 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients were randomly divided with Random Allocation software, Blinding description: Patients have informed consent for intervention, but they dont know which group they are in. The outcome evaluator is also unaware of the patient group The data analyst will analyse the data in 3 groups that the drug used by each group is unknown. 2-3 Intubation. Intervention 1: First Intervention group: In this group, each patient is given 0.05 mg/kg Ephedrine intravenous before injection of Atracurium. Intervention 2: Intervention group: In this group, each patient is given 0.5 mg/kg Ketamine intravenous before injection of Atracurium. Intervention 3: Control group: In this group each patient is given 5cc Normal Saline intravenous as a placebo before injection of Atracurium. Yes - There is a plan to make this available What will be shared: The Analysis of the main outcome data will be published When: 6 months later To whom: Reseachers Conditions: __ Where to obtain: Mohammad ghasemi Tel : 09127852900 How to obtain: ___ Comments:
public Mohammad Ghasemi
Shariati hospital, North Amir Abad Ave
Tehran Iran (Islamic Republic of) 3415719451 +98 28 3333 4646 mhd.ghasemi371@gmail.com Tehran University of Medical Sciences scientific Mohammad Ghasemi
Shariati hospital, North Amir Abad Ave
Tehran Iran (Islamic Republic of) 3415719451 +98 28 3333 4646 mhd.ghasemi371@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Patients with ASA score 1 or 2 Patients undergoing elective surgery 8 hours fasting at least 15 years 65 years Both Patients with BMI between 16.5 to 35 Liver or kidney disease Patients with mallampati test 3 or more Patients with HTN or IHD in one year ago T88.4 Failed or difficult intubation Prevention Prevention Prevention First Intervention group: In this group, each patient is given 0.05 mg/kg Ephedrine intravenous before injection of Atracurium Intervention group: In this group, each patient is given 0.5 mg/kg Ketamine intravenous before injection of Atracurium Control group: In this group each patient is given 5cc Normal Saline intravenous as a placebo before injection of Atracurium Shorten the onset time of the effect of Atracurium. Timepoint: 2 minutes after the administration of fentanyl until 2 response in Train Of Four at 10 seconds intervals. Method of measurement: Nerve Stimulator ( train of four ). Tehran University of Medical Sciences Approved 2019-05-29 Ethics committee of Tehran University of Medical Sciences Shariati hospital, North Amir Abad Ave Tehran Tehran Iran (Islamic Republic of)