IRCT20100127003210N17 IRCT 2019-08-23 Shahid Beheshti University of Medical Sciences Levofloxacin in Hematopoetic stem cell transplant Comparison of The Efficacy of Levofloxacin and Ciprofloxacin in Prevention of Bacterial Infection in Allogeneic Hematopoietic Stem Cell Transplant Recipients 2019-02-20 anticipated 60 Complete https://irct.ir/trial/40982 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The random allocation sequence will computer generate and consist of series of group number (either 1 = A or 2 = B) for each consecutive patient. Block randomization method will use and each block will be consist of 10 patients. Each block includes 5 patients who will receive Vitamin E and 5 patients from control group. 3 antibiotic prophylaxis in hematopoetic stem cell transplantation. Intervention 1: Intervention group: receiving Levofloxacin by dose of 500 mg per day in form of one tablet which is taken orally or intravenously if the patient is unable to take orally from day 1 post transplantation for 21 days or detecting fever or engraftment. Intervention 2: Intervention group: receiving Ciprofloxacin by dose of 500 mg every 12 hours in form of one tablet which is taken orally or intravenously if the patient is unable to take orally from day 1 post transplantation for 21 days or detecting fever or engraftment. Yes - There is a plan to make this available What will be shared: Primary outcome data after making unrecognizable will be released When: 6 months after publishing the results primary outcome data will be released To whom: Researchers after allowance of corresponding author could have the permission to have the data Conditions: Performing any analysis will be allowed only with the permission of corresponding author Where to obtain: Corresponding author How to obtain: After requesting to reach data, corresponding author will check the allowance, then the researcher will be informed about it Comments: