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IRCT20190415043284N1 IRCT 2019-08-15 Ahvaz University of Medical Sciences Short Term Magnesium Preventation In Menstrually Related Migraine (MRM) Studying effectiveness of Short Term oral Magnesium supplement Prophylaxis In Menstrually Related Migraine (MRM) in women in reproductive ages : A Randomized Controlled Trial 2019-01-21 anticipated 60 Complete https://irct.ir/trial/40885 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Participants assign to comparison groups (allocation sequence) with random allocation rule (a form of restricted randomisation procedures- after sample taking finished, we put magnesium and placebo papers, half and half number in a sortition container and bring them out randomly to make an allocation sequence.) and this allocation conceals by central randomization, Blinding description: Participants are unaware of who is receiving the real treatment and by means of a third party who collected data and bring them anonymous to assessor and and analyser blinding done. 3 Menstrually Related Migraine (MRM). Intervention group: each patient during 3 continuous menstrual cycles, taking one and half (375 milligrams) of 250 miligrames magnesium oxide pills from Jalinous Pharmaceutical company daily and records headaches from 2 days before menstruation up to third day of mens. Control group: each patient during 3 continuous menstrual cycles, taking one and half of placebo pills daily and records headaches from 2 days before menstruation up to third day of mens.. Yes - There is a plan to make this available What will be shared: Data about magnesium prophylaxis effects on menstrually related migraine headaches and its Side effects will share. When: at least 6 months after the date that results have been published. To whom: researchers who work for universities Conditions: To investigate weak points of this study to obtain and start a new and more useful work Where to obtain: Dr Ehsan Mohammadiani Nejad, neurology ward, Ahvaz Jundishapur university of medical sciences How to obtain: Deliver a request containing exact description of reasons for this request and make a list of the exact data which is needed, to the neurology group. this request will be checked as soon as possible and will be answered. Comments:

public Ehsan Mohammadiani Nejad

Neurology ward, Golestan hospital, Farvardin Aven., Golestan Blv..

Ahvaz Iran (Islamic Republic of) 33118-61357 +98 61 3374 3001 p.yabande@gmail.com Ahvaz University of Medical Sciences scientific Ehsan Mohammadiani Nejad

Neurology ward, Golestan hospital, Farvardin Aven., Golestan Blv..

Ahvaz Iran (Islamic Republic of) 33118-61357 +98 61 3374 3001 p.yabande@gmail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) patients affected by menstrually related migraine according to 3rd edition of The International Classification of Headache Disorders regular mense 20 years 50 years Female chronic diarrhea renal failure nephrolithiasis myasthenia gravis patients anti hypertensive drug usage particularly calcium channel blocker users diabetic patients who has insulin resistance state pregnancy or planned pregnancy; ; menstrual migraine [14] breast feeding women non migraine headache psychiatric illness according to DSM5 criteria chronic systemic illness dependence or abuse of drugs intake of antidepressants, neuroleptics, minor or major tranquillizers, drugs used for the treatment of affective disorders (e.g. lithium, carbamazepine), antiepileptics bradrychardia anti coagulant and antiplatelet usage pure menstrually migraine Prevention Intervention group: each patient during 3 continuous menstrual cycles, taking one and half (375 milligrams) of 250 miligrames magnesium oxide pills from Jalinous Pharmaceutical company daily and records headaches from 2 days before menstruation up to third day of mens. Control group: each patient during 3 continuous menstrual cycles, taking one and half of placebo pills daily and records headaches from 2 days before menstruation up to third day of mens. Headache attacks of menstrually related migraine. Timepoint: 4 questionnaires are filled: the first one at the sampling time and 3 others during 3 continuous menstrual cycles which the participant take pills. Method of measurement: questionnaire. Headache frequency, intensity, prolongation, amount of analgesic drugs and resulting palliation. Timepoint: 4 questionnaires are filled: the first one at the sampling time and 3 others during 3 continuous menstrual cycles which the participant take pills. Method of measurement: Each questionnaire contains a calendar with blanks to record: the exact date of menstruation starting date, headache days, headache intensity ( 1 to 10 scale), each headache attack prolongation (hours), number of analgesic pills to pain relief and resulting palliation (describes with excellent, good, intermediate and poor response). Ahvaz University of Medical Sciences Approved 2018-05-05 Ethics Committee of Ahvaz Jundishapur University of Medical Sciences No. 3,Mahsa building, Alley 13, Khadem Sadeq Ave., Amir Kabir Blv., shiraz Ahvaz Khouzestan Iran (Islamic Republic of)