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IRCT20180903040936N2 IRCT 2019-09-02 Arak University of Medical Sciences Comparison of the Effect of Dexmedetomidine, Remifentanil and Metoral on Reducing Bleeding and Surgery Satisfaction During Rhinoplasty Comparison of the Effect of Dexmedetomidine, Remifentanil and Metoral on Reducing Bleeding and Surgery Satisfaction During Rhinoplasty 2019-08-15 anticipated 75 Complete https://irct.ir/trial/40751 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: This study is a double-blind randomized clinical trial of patients undergoing rhinoplasty in the Amir Kabir hospital of Arak. A sample of 75 patients with a candidate rhinoplasty that has been studied by a cardiologist and selected by a cardiologist is selected and divided into three randomly assigned randomized complete sets randomly divided into three groups: Remifentanil, Metoral, and Dexmedetomidine, Blinding description: The drugs required for infusion are prepared for anesthetist by the anesthetist and in each of the 3 groups 50 cc syringes are provided with a similar appearance to the partner in order to provide infusion to the patients. also intern responsible for the plan who is responsible for completing the questionnaire, is not aware of the type of study group. Syringes containing infusion solutions are placed on the A, B, and C adhesives for the patients, provided with a syringe A, B and C. 3 Comparison of the Effect of Dexmedetomidine, Remifentanil and Metoral on Reducing Bleeding and Surgery Satisfaction During Rhinoplasty. Intervention 1: Intervention group: After the anesthetic induction, the patients are examined and placed under the ventilator, then they are done and ready for rhinoplasty. Then, for patients in the first group, 0.5 mg / kg / h will be dosed as Dexmedetomidin infusion. Intervention 2: Intervention group: Intervention group: After the anesthetic induction, the patients are examined and placed under the ventilator, then they are done and ready for rhinoplasty. Then, for patients in the first group, 50-100µ / kg /h will be dosed as Remifentanil infusion. Intervention 3: Intervention group: Intervention group: After the anesthetic induction, the patients are examined and placed under the ventilator, then they are done and ready for rhinoplasty. Then, for patients in the first group, 50 mg will be dosed as Metoral infusion. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Narges Anousheh
Ashrafi Esfahani Highway
Tehran Iran (Islamic Republic of) 1476985574 +98 21444976300 www.nargesanousheh1994@gmail.com Arak University of Medical Sciences scientific Narges Anousheh
Ashrafi Esfahani Highway
Tehran Iran (Islamic Republic of) 1476985574 +98 21444976300 www.nargesanousheh1994@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) All patients with Rhinoplasty who referred to Amir Kabir Hospital in Arak Patients aged 18 to 50 years 18 years 50 years Both Patients who have had a specific heart attack or even a heart attack during the operation Patients who are unable to get metroral due to early bradycardia. I95.2: Hypotension due to drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: After the anesthetic induction, the patients are examined and placed under the ventilator, then they are done and ready for rhinoplasty. Then, for patients in the first group, 0.5 mg / kg / h will be dosed as Dexmedetomidin infusion. Intervention group: Intervention group: After the anesthetic induction, the patients are examined and placed under the ventilator, then they are done and ready for rhinoplasty. Then, for patients in the first group, 50-100µ / kg /h will be dosed as Remifentanil infusion Intervention group: Intervention group: After the anesthetic induction, the patients are examined and placed under the ventilator, then they are done and ready for rhinoplasty. Then, for patients in the first group, 50 mg will be dosed as Metoral infusion. Average MAP of patients. Timepoint: Immediately, 5 minutes, 15 minutes, 30 minutes, 45 minutes, 60 minutes, 75 minutes, 90 minutes and 2 hours after anesthesia. Method of measurement: Mercury and digital pressure gauge device. Average heart rate of patients. Timepoint: Immediately, 5 minutes, 15 minutes, 30 minutes, 45 minutes, 60 minutes, 75 minutes, 90 minutes and 2 hours after anesthesia. Method of measurement: Cardiac monitoring. Average scour of bleeding during surgery. Timepoint: During surgery. Method of measurement: By check list and according to the amount of gas used to prevent bleeding. Surgeon Satisfaction. Timepoint: After the completion of surgery. Method of measurement: Based on checklist. Arak University of Medical Sciences Approved 2019-05-05 Ethics committee of Arak University of Medical Sciences Arak University of Medical Sciences,next to Amiralmomenin Hospital, Basij Square,Sardasht Arak Markazi Iran (Islamic Republic of)