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IRCT201106191197N10 IRCT 2013-12-17 Vice Chancellor for research of Tabriz Uniersity of Medical Sciences Effects of Nigella Sativa in Obese Women Effects of Nigella Sativa Oil Suplementation with Weight Loss Diet on Some Anthropometric Indices, Lipd Profile and Some Inflammatory Factors in Obese Women with Various Polymorphisms of Adiponectin gene and Type 2 Isoform Peroxisome proliferator-activated receptor gamma 2013-12-22 anticipated 82 Complete https://irct.ir/trial/406 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization is performed by permuted block randomization (block size: 2) using RAS software. 2 Obesity. Intervention 1: Intervention group: Comsumption of 3 gr/day Nigella Sativa oil provided by Daana pharmaceutical company(1 gr soft gel capsule 3 times a day) with weight loss diet for 2 months. Intervention 2: Control group: 3 gr/day sunflower oil provided by Daana pharmaceutical company(1 gr soft gel capsule 3 times a day) with weight loss diet.
public Nazli Namazi
Health and Nutrition Faculty,Tabriz University of Medical Sciences, Attar Neyshabori Street, Golgasht Street
Tabriz Iran (Islamic Republic of) +98 41 1334 1113 nazli.namazi@yahoo.com Tabriz University of Medical Sciences, Health and nutrition faculty scientific Dr. Reza Mahdavi
Health and Nutrition Faculty,Tabriz University of Medical Sciences, Attar Neyshabori Street, Golgasht Street
Tabriz Iran (Islamic Republic of) +98 41 1334 1113 mahdavir@tbzmed.ac.ir;nazli.namazi@yahoo.com Nutrition Research Center, Health and nutrition faculty, Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: women with 25-50 years old; Body Mass Index between 30 to 34.9 kg/m2; following no weight loss diet or any special diet during 6 months ago. Exclusion criteria: taking vitamin-mineral supplement during 3 months ago;taking anti-inflammatory medications, losing weight drugs, asprin and other anticoagulant medications; cardiovascular diseases, liver, kidney and tyroid disorders,type 1 or 2 diabetes; pregnancy and lactation; smoking 25 years 50 years Female E66.0 Obesity due to excess calories Other Placebo Intervention group: Comsumption of 3 gr/day Nigella Sativa oil provided by Daana pharmaceutical company(1 gr soft gel capsule 3 times a day) with weight loss diet for 2 months Control group: 3 gr/day sunflower oil provided by Daana pharmaceutical company(1 gr soft gel capsule 3 times a day) with weight loss diet Anthropometric indices. Timepoint: Beginning and at the end of the intervention(after 2 months). Method of measurement: Height,weight,waist circumference,hip circumference mesearment. Inflammatory factors. Timepoint: Beginning and at the end of the intervention( after 2 months). Method of measurement: Measurement of IL-6,TNF-α and hs-CRP with special kits. Lipid profile. Timepoint: Begining and at the end of study(2 months). Method of measurement: Measurment of HDL-C,LDL-C,TG,TC with special kits. Frequency of adiponectin and PPAR gamma-2 genotypes. Timepoint: Begining of intervention. Method of measurement: PCR-RFLP. Nutrition Research Center Vice Chancellor for research of Tabriz Uniersity of Medical Sciences Nutrition Research Center Approved 2013-11-18 Ethics committee of Tabriz University of Medical Science Tabriz University of Medical Science, Attar Neyshaboori Street Tabriz Iran (Islamic Republic of)