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IRCT20190701044070N1 IRCT 2019-07-06 Mazandaran University of Medical Sciences The effect of simvastatin on reducing tooth pain Local clinical effect of simvastatin tablets on pain after maxillary premolar tooth extraction in patients recommended for orthodontic treatment 2018-10-28 anticipated 10 Complete https://irct.ir/trial/40576 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: To assign each pair to the control group or the intervention based on the first or second time, using the random numbers table, 10 people will be assigned to the intervention group and 10 will be assigned to the control group. Patients with systemic problems, or certain drugs, as well as addicts and smokers will be removed from the study group, and only healthy patients will be examined. The criteria for entering the study can be from the age of 35 to 18 years, and the orthodontic order for the removal of each of the first two premolars in the right and left upper jaw. Also, the teeth should not have periapical radiographic changes and can also be removed by forceps and local anesthetics. The pain according to the patient's own opinion, based on the subjective criteria and according to the Visual Analog Scale (VAS), will be available at the intervals before, 30 minutes later, 6 hours, 12 hours and 24 hours after surgery. . In addition, the patient is urged to visit the department 7 days a day to examine and pull sutures, Blinding description: This clinical trial is parallel, randomized, and blind clinical trials. In the intervention group, the gelatin sponge coated with simvastatin (10 mg, combined with saline) (Poursina, Tehran, Iran) was placed in silence and then sutured with suture wrap 3 to 3 vikril. In the control group, just after washing, only gelatin sponge is placed and the silent just sutures. 0 (exploratory trials) tooth pain. Intervention group: The first premolar was the one used with simvastatin. Yes - There is a plan to make this available What will be shared: Clinical Effect of Simvastatin Tablets on the Post-Injury of Premolar Maxillary Pain in Patients Referring to Orthodontic Treatments When: It's ready To whom: University - Supervisor - Student Conditions: To reduce tooth pain and under any circumstances Where to obtain: Student How to obtain: University permit - Propeller - Research - Conclusion - Thesis Comments:
public Dr. Reza Mofidian
Mazandaran University of Medical Sciences and Health Services, Beginning of Valiasr highway, Sari, Mazandaran
sari Iran (Islamic Republic of) 48157-33971 +98 11 3304 4001 reza_mofidian@yahoo.com Mazandaran University of Medical Sciences scientific Dr. Reza Mofidian
Mazandaran University of Medical Sciences and Health Services, Beginning of Valiasr highway, Sari, Mazandaran
sari Iran (Islamic Republic of) 48157-33971 +98 11 3304 4001 reza_mofidian@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) The orthodontic order to extract of each 2 maxillary premolars for future orthodontic treatment 18 years 35 years Both Treatment - Drugs Intervention group: The first premolar was the one used with simvastatin The amount of pain. Timepoint: Before, 30 minutes later, 6 hours, 12 hours and 24 hours after surgery. Method of measurement: The VAS is a 10-cm linear scale that is graded from zero to ten and is zero in the no-pain sense and ten most severe pain. After considering the line, the patient determines the amount of pain on the line, and then the pain is calculated based on millimeters from the origin of zero. Mazandaran University of Medical Sciences Approved 2019-04-08 Ethics Committee of Mazandaran University of Medical Sciences medical university of mazandaran, Vali asr Ave., sari, Iran Sari Mazandaran Iran (Islamic Republic of)