IRCT20180329039159N2 IRCT 2019-08-05 University of Palermo Effect of PRP to prevent MRONJ after dental extraction Effect of platelet-rich plasma (PRP) on dental extraction in patients at risk of medication related osteonecrosis of the jaw 2015-06-10 anticipated 20 Complete https://irct.ir/trial/40369 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Prevention. N/A medication related osteonecrosis of the jaw. Intervention group; the surgical protocol expected: 1) Chlorhexidine 0,2% mouthwashes 30 ml swished up to 60 seconds; 2) local anesthesia achieved using 3% mepivacaine hydrochloride without adrenaline; 3) elevation of a full-thickness mucoperiosteal flap; 4) tooth luxation and avulsion were gently performed with elevators and forceps; 5) if necessary, osteoplasty 6) debridement of the post-extraction socket with miller surgical curette and irrigation of the sockets with rifamycin sodium; 7) application of a single dosage of autologous platelet-rich plasma (Plateltex ACT System ®, Biomed, Modena, IT) ; 8) tension-free soft tissue closure. To prepare the PRP and to induce its gelation, the materials provided by the manufacturer were used and the provided instructions followed [Mazzucco L, Balbo V, Cattana E, Borzini P. Platelet-rich plasma and plateletgel preparation using Plateltex. Vox Sang. 2008 Apr;94(3):202-8.]. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information