IRCT20190618043923N2 IRCT 2019-07-08 Tabriz University of Medical Sciences Effect of tapontadol and oxycodone in pain control Effect of premedication with Tapentadol and Oxycodone sustain release for post operative pain control in Laparascopic cholecystectomy 2019-08-23 anticipated 60 Complete https://irct.ir/trial/40318 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: All patients will be under the same anesthesia method and will be operated by a surgeon, Randomization description: Random Blocking Method and RASS Software, allocation concealment will ensured by sequentially numbered opaque sealed envelopes, Blinding description: The participants, the main investigator, the person assessing the outcomes, and the person responsible for statistical analysis of the data will be kept blinded to assignment. Medications will be provided to the examiners in closed envelopes, which are labeled by a technician other than the original research members. 2-3 Patients with calculus of gallbladder candidated for laparoscopic cholecystectomy. Intervention 1: Intervention group 1: Receiving Pre-treatment regimens of one oral tablet of tapentadol 75 mg (NUCYNTA) branded by Collegium Pharmaceutical, Inc., an hour before surgery, with naproxen plus metoclopramide 10 mg. Intervention 2: Intervention group 2: Receiving Pre-treatment regimens of one oral tablet of Oxycodone 15 mg (PHAROXY) branded by Collegium Pharmaceutical, Inc., an hour before surgery, with naproxen plus metoclopramide 10 mg. Intervention 3: Control group: No premedication regimen which recieve naproxen plus metoclopramide 10 mg. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.