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IRCT20190619043948N1 IRCT 2020-04-11 Arak University of Medical Sciences Effect of magnesium on Nephrotoxicity of Carboplatin Kidney-protective Effect of Magnesium Supplementation in Carboplatin-containing Chemotherapy for Pediatric Cancer 2019-11-06 anticipated 50 Complete https://irct.ir/trial/40309 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: At the beginning of the study, the demographic data collection form will be completed, and if you have the conditions to enter the study of patients receiving carboplatin by coin toss (heads for the intervention group and tails for the control group) randomly, to the two groups receiving magnesium supplement Mg + And do not receive Mg-magnesium. 2-3 Nephrotoxicity of Carboplatin. Intervention 1: Control group: Patients receive placebo tablet (Jalinus brand) orally for two weeks each day before Carboplatin therapy. Intervention 2: Intervention group: Patients receive magnesium oxide 250 mg tablet (Jalinus brand) orally for two weeks each day before Carboplatin therapy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no more information
public Marzie Alizade Hadadhania
No. 17, Sahand Deadend, Sepidar Alley, Naderi Shomali Ave.
arak Iran (Islamic Republic of) 3413719451 +98 28 3333 7711 marzie.alizade@gmail.com Arak University of Medical Sciences scientific Marzie Alizade Hadadhania
No. 17, Sahand Deadend, Sepidar Alley, Naderi Shomali Ave.
arak Iran (Islamic Republic of) 3413719451 +98 28 3333 7711 marzie.alizade@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) Children over 2 years of age with malignancy receiving Carboplatin 2 years 16 years Both Kidney disorder with GFR under 30 Receiving other platinum drugs or other nephrotoxic drugs Receiving antibiotics N14.1 Nephropathy induced by other drugs, medicaments and biological substances Placebo Treatment - Drugs Control group: Patients receive placebo tablet (Jalinus brand) orally for two weeks each day before Carboplatin therapy. Intervention group: Patients receive magnesium oxide 250 mg tablet (Jalinus brand) orally for two weeks each day before Carboplatin therapy. Blood urea nitrogen. Timepoint: Before intervention and 2 and 7 days later. Method of measurement: Mass spectrometry. Creatinine. Timepoint: Before intervention and 3 and 7 days later. Method of measurement: Mass spectrometry. Glomerular filtration rate. Timepoint: Before intervention and 3 and 7 days later. Method of measurement: Schwartz formula, by calculation. Arak University of Medical Sciences Approved 2019-08-04 Ethics committee of Arak University of Medical Sciences No. 17, Sahand Deadend, Sepidar Alley, Naderi Sholmali Ave. arak Markazi Iran (Islamic Republic of)