IRCT20121110011424N5 IRCT 2019-09-25 Tehran University of Medical Sciences Effect of Memantine on epileptic patients Effects of Memantine on cognitive profile of patients with epilepsy: A randomized, double-blind, placebo-controlled clinical trial 2018-08-23 anticipated 60 Complete https://irct.ir/trial/40264 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were divided into 2 groups with sequentially numbered method( randomization with the random number builder software), Blinding description: Participants and doctors are both blinded about the treatment. After taking the patient's history, the researcher give a sealed envelope including code A (Memantine) or code B (placebo) to the patient. Then, patient will give that wrapped envelope to the pharmacist and received the assigned drug (drug A or B which are kept in the same cover from the company). The pharmacist will record patients' name and drug codes without knowing the type of the drug and this information will be kept until the end of the study. 3 Epilepsy. Intervention 1: Intervention group: 5 mg Memantine oral tablet once a day for 8 weeks and then 10 mg once a day for another 8 weeks with caution. Intervention 2: Control group: placebo once a day for 16 weeks. Yes - There is a plan to make this available What will be shared: Clinical and demographic data will be available When: When data was published To whom: Public Conditions: For scientific use only Where to obtain: Email (PI) How to obtain: PI approval Comments: