IRCT20130521013406N5 IRCT 2019-07-07 Shiraz University of Medical Sciences Phenytoin Mucoadehesive Tablet versus Mouthwash in treatment of Oral Mucositis Efficacy of Phenytoin mucoadhesive tablet versus mouthwash on chemotherapy induced oral mucositis 2014-04-21 anticipated 40 Complete https://irct.ir/trial/40243 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: block randomized study. 2-3 chemotherapy induced oral mucositis. Intervention 1: Intervention group: phenytoin mucoadhesive tablet Mucoadhesive tablets are prepared by direct compression method. The ingredients (10 mg sodium phenytoin and the remaining ingredient was HPMC: Chitosan; NaCMC, 25:25:50 w/w %) are weighed accurately and mixed by trituration in a mortar by pestle for 15 minutes. Then all of the ingredients are passed through sieve no. 100. Finally the mixture is compressed to tablet using Korsch single punch compression machine (ERWEKA, German).Each day, two tablets should be attached inside the cheek until they are dissolved and the treatment should be continued until the complete healing of oral lesions or for a maximum of two weeks. Intervention 2: Intervention group: Phenytoin mouthwash Appropriate amount of sodium phenytoin is dissolved in 1 L of distilled water which contain 0.1% Tween 80 and Disodium hydrogen phosphate (2.38 g/L), with adjusted pH on 7.0±0.02 using phosphoric acid. The final concentration of phenytoin mouthwash is 0.333 mg/mL. patients are instructed to rinse (gargle) 10 ml of the solution for one minute, three times a day (to distribute evenly to all parts of the oral tissues), and then spit (to minimize the systemic absorption). They are told to avoid eating during the first hour after treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no further information