IRCT20140310016917N8 IRCT 2019-07-11 Vice chancellor for research of Guilan University of Medical Sciences Inhaled heparin in pneumonia Study of the effect of inhaled heparin on duration of antibiotic therapy in patients with ventilator associated pneumonia 2019-06-22 anticipated 42 Complete https://irct.ir/trial/40133 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Out of 42 subjects who entered the study by random block method, Individuals are randomly assigned to both interventional and non-interventional groups (with placebo)by statistical random generator software, Blinding description: Once the subjects in the study groups have been identified, the drug and placebo are placed in the same syringes as they are in appearance, and thus patients will not be informed of the contents inside it. 2-3 VENTILATOR ASSOCIATED PNEUMONIA(VAP). Intervention 1: Intervention group: after appropriate randomization drug (nebulized heparin in this group) in dose of 2 cc (10,000 heparin units) every 4 hours is given through a jet nebulizer located 30 cm in the tracheal tube at the inspiratory arm of ventilator.Other measures will be exactly the same as the recipients of standard pneumonia treatment (control group).The Heparin ampoule is supplied by the Caspian Company and is at 5000 units per cc. Intervention 2: Control group: after appropriate randomization drug (distilled water in this group) in dose of 2 cc every 4 hours is given through a jet nebulizer located 30 cm in the tracheal tube at the inspiratory arm of ventilator and standard treatment consistent of antibiotics in appropriate for the local prevalency in the ICU initially was started and then continued on the basis of culture of pulmonary secretions until the pro calcitonin serum level is in the non infected stage or at most 14 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is To protect the secrets of patients and to observe ethics of study