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IRCT138806301197N2 IRCT 2010-03-20 Nutritional Research Center Tabriz University Of Medical Science Effects of alpha lipoic acid supplementation on serum level of visfatin, markers of oxidative stress, inflammation and insulin resistance in patients with chronic renal failure undergoing hemodialysis. Effects of alpha lipoic acid supplementation on serum level of visfatin, markers of oxidative stress, inflammation and insulin resistance in patients with chronic renal failure undergoing hemodialysis. 2010-01-20 anticipated 60 Complete https://irct.ir/trial/401 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A chronic renal failure. Intervention 1: Daily consumption of alpha lipoic acid capsule (600 mg) for 8 weeks. Intervention 2: daily consumption of placebo for 8 weeks.
public Reza mahdavi
Tabriz University of Medical Sciences
Tabriz Iran (Islamic Republic of) +98 41 1335 7580 mahdavir@tbzmed.ac.ir t.khabbazi@gmail.com Tabriz University Of Medical Sciences scientific Tannaz Khabbazi
Tabriz University Of Medical Sciences
Tabriz Iran (Islamic Republic of) +98 41 1335 7580 t.khabbazi@gmail.com Tabriz University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: obtaining informed consent, being on hemodialysis for more than 6 months, receiving 3 times hemodialysis each week Exclusion criteria: hepatitis and other infections less than 20 years, receiving any NSAID and SAID, alpha lipoic acid supplement, vitamin C, vitamin E, valporic acid in the month prior to the study, presence of gastrointestinal disorders, being candidate for kidney transplantation, pregnancy or lactation, smoking, possibility of any side effect for consumption of the supplement 20 years no limit Both N18.0 End-stage renal disease Placebo Daily consumption of alpha lipoic acid capsule (600 mg) for 8 weeks daily consumption of placebo for 8 weeks Visfatin. Timepoint: baseline and after 8 weeks. Method of measurement: ELIZA. TAC. Timepoint: baseline and after 8 weeks. Method of measurement: calorimetric method. MDA. Timepoint: baseline and after 8 weeks. Method of measurement: flurimetric method. HsCRP. Timepoint: baseline and after 8 weeks. Method of measurement: immunoturbidometric method. Fasting insulin. Timepoint: baseline and after 8 weeks. Method of measurement: ELIZA. Fasting Glu. Timepoint: baseline and after 8 weeks. Method of measurement: calorimetric method. HOMA-IR. Timepoint: baseline and after 8 weeks. Method of measurement: formula. Tchol. Timepoint: baseline and after 8 weeks. Method of measurement: calorimetric method. Serum TG. Timepoint: baseline and after 8 weeks. Method of measurement: calorimetric method. Serum HDL-c. Timepoint: baseline and after 8 weeks. Method of measurement: calorimetric method. Serum LDL. Timepoint: baseline and after 8 weeks. Method of measurement: Friedelwald formula. Body Mass Index (BMI). Timepoint: baseline and after 8 weeks. Method of measurement: calculation. Total Daily Calorie. Timepoint: baseline and after 8 weeks. Method of measurement: 24h recalls. Daily protein. Timepoint: baseline and after 8 weeks. Method of measurement: 24h recalls. Daily Fat. Timepoint: baseline and after 8 weeks. Method of measurement: 24h recall. Daily charbohydrate. Timepoint: baseline and after 8 weeks. Method of measurement: 24h recall. Update 19 Feb 2011: serum albomin. Timepoint: Update 19 Feb 2011: baseline and after 8 weeks. Method of measurement: Update 19 Feb 2011: Bromocresol Green method. Health benefits for patients. Timepoint: baseline and weekly monitoring. Method of measurement: observation and evaluation of biochemical parameters. Vice Chancellor for Research, Tabriz University Of Medical Science Drug Applied Research Center Tabriz University Of Medical Sciences Nutritional Research Center Tabriz University Of Medical Science Vice Chancellor for Research, Tabriz University Of Medical Science Drug Applied Research Center Tabriz University Of Medical Sciences Approved 2009-10-05 The Research Ethics Committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences Tabriz Iran (Islamic Republic of)