IRCT201404303862N12 IRCT 2014-07-03 Mashhad University of Medical Sciences, Vice Chancellor for Research Evaluation of laser efficacy in treatment of cutaneous leishmaniasis lesion Evaluation of fractional CO2 laser efficacy in treatment of atrophic scar of cutaneous leishmaniasis 2013-04-21 anticipated 40 Complete https://irct.ir/trial/4009 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Cutaneous Leishmaniasis. Cleansing of location by isopropyl alcohol 70%, and then dressing is performed for local anesthesia. After 45 minutes, the location is washed and dried. Treatment will be performed with laser beam size 120 micron and pals energy between 50-90 mj and densitometry between 50-100 spot/cm2 in three sessions of treatment with duration of one month..

public Dr Hamid Reza Moghimi

Ghaem Hospital, Ahmad Abad Street

Mashhad Iran (Islamic Republic of) +98 51 1841 0135 src@mums.ac.ir Mashhad University of Medical Sciences scientific Dr Mahnaz banihashemi

Cutaneous Leishmaniasis Research center, Ghaem hospital, Ahmad Abad Street

Mashhad Iran (Islamic Republic of) +98 51 1801 2851 banihashemim@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age more than 12 years old; informed consent of patient for participating in study; atrophic scar in hand or face with duration of improvement more than one year Exclusion criteria: patients with chronic disease like diabetes and collagen vascular diseases that have a problem in scar healing; hypertrophic or keloid scars; history for receiving isotretinoin during last year; pregnancy or breastfeeding; immunodeficiency patients like patients under immunosuppressive medicines; patients who don’t complete treatment period or don’t refer for follow ups; skin type VI; history of radiotherapy in laser locations; patients with positive coiner disease like psoriasis and vitiligo 18 years 60 years Both B55.1 Cutaneous Leishmaniasis Treatment - Devices Cleansing of location by isopropyl alcohol 70%, and then dressing is performed for local anesthesia. After 45 minutes, the location is washed and dried. Treatment will be performed with laser beam size 120 micron and pals energy between 50-90 mj and densitometry between 50-100 spot/cm2 in three sessions of treatment with duration of one month. Complete healing. Timepoint: For the first before intervention, then during therapy sessions, and 3 and 6 months after the last treatment session. Method of measurement: Measuring the size of induration and scar. Side effects including erythema, edema, petechiae, dispigmentation and scar. Timepoint: start of therapy, 3 and 6 months after the last treatment session. Method of measurement: Physical exam. Mashhad University of Medical Sciences, Vice Chancellor for Research Approved 2010-09-23 Ethics Committee of Mashhad University of Medical Sciences Central Building of Mashhad University of Medical Sciences (Ghorshi),Daneshgah 16, Daneshgah Street Mashhad Iran (Islamic Republic of)