IRCT20090613002027N18 IRCT 2020-02-06 Mazandaran University of Medical Sciences The effect of timolol gel on wound healing in patients with skin transplantation Comparison of efficacy and safety of timolol gel versus placebo in wound healing of patients with split-thickness skin grafts 2020-02-20 anticipated 60 Complete https://irct.ir/trial/39738 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: For allocation concealment, a 5 numbers digital code obtained from Excel software will be assigned for each patient. Participants will be randomly assigned to the study groups according to block randomization with 4 patients in each block. Random allocation software will be used for block randomization, Blinding description: For blinding purpose, instead of labels A or B, each participant will be assigned a unique fore-digit code obtained by the Excel program. Both timolol gel and placebo will be prepared in containers with equal appearance. Participants, physicians and assessor will be blinded regarding the grouping of participants. 2-3 Candidate Patients Receiving Skin Transplant. Intervention 1: First Intervention: patients receiving 0.25% timolol gel The first dose will be applied immediately after the operation. The gel will be used twice daily for the first 48 hr and then daily until 14 days. The first four doses will be applied when the patient is in the hospital and then twelve single-dose units will be given for home use. Intervention 2: Second Intervention: patients receiving gel base without timolol The first dose will be applied immediately after the operation. The gel will be used twice daily for the first 48 hr and then daily until 14 days. The first four doses will be applied when the patient is in the hospital and then twelve single-dose units will be given for home use. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no plan for publishing the protocol of the study because it is accessible in IRCT.